Giloy powder: Herbal immunity booster for better health & digestion | Most Searched Products

Giloy powder: Herbal immunity booster for better health & digestion | Most Searched Products

  • June 17, 2021
When you are looking for herbal immunity boosters, giloy and its supplements are quite popular in India. Giloy is not just used for reducing fever but is even a great choice for strengthening the immune system, keeping a check on blood pressure and sugar levels, improving metabolism, promoting healthy digestion and more. If you do not want to go for giloy juice, tablets or capsules, you can even take this immunity booster in the form of giloy powder.

Focus on your immune system and take the help of one of these packs of giloy powder that you can buy online. Have a look at this list of some of the most popular options that are worth your money and improve your overall health using natural products.

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If you are finding it hard to prepare kadha or other immunity booster drinks using giloy stem, you can take the help of this pack of stem powder. This organic powder is easy to add to the diet and can be used in multiple ways. Besides boosting immunity, it can help your body detox, reduce mental and physical stress and even reduce anxiety to an extent.

You can have this giloy powder with warm milk or water. The shelf life of this pack is 24 months from the date of manufacturing if you store it well.


In the market of healthcare supplements and products, Baidyanath has been a trusted name in India for years. This giloy powder by the brand is a great immunity booster and even helps in eliminating stomach disorders. So, your digestive system will stay healthy and the food that you take is digested properly.

You can take 1-2 spoons of this powder with lukewarm water as directed by your physician to see a visible difference in your overall health in a few days. Regular consumption of this powder can even keep minor seasonal infections away.


This pack of giloy powder can be another good option to consider buying online for your overall health and immunity. This powder is sourced from forests and is organic. So, you need not think too much before adding this herbal immunity booster to your diet plan. This powder is free from harmful preservatives and additives to ensure that the goodness of giloy is not reduced.

You can boil this powder in water along with tulsi and other herbal ingredients to make your immunity booster drink whenever you want.


This pack of giloy powder can be another affordable choice to consider for your immune system and overall health. This powder is made from the leaves of the giloy plant and can even help you reduce stress and anxiety to an extent. So, you can use it as an immunity booster and stress-buster.

Store this giloy powder in an airtight container to avoid the loss of nutrients or contamination due to exposure to dust, moisture or pollutants.


This giloy powder can be another affordable immunity booster that you can buy online. This powder is made from the stem of the giloy plant to give you plenty of nutrients and allow you to prepare various immunity booster drinks easily at home. Available in a zip-lock pouch, it is easy to store this giloy powder at home.

You can have 1 spoon of powder with water as per the instructions of your doctor to boost your immunity.

Get it here.



Look for other options in giloy powder here.

DISCLAIMER: The Times of India’s journalists were not involved in the production of this article.

Next-Generation COVID-19 Vaccines Could Stimulate Another Arm of the Immune System

Next-Generation COVID-19 Vaccines Could Stimulate Another Arm of the Immune System

  • June 17, 2021

A new study looking at the way human cells activate the immune system in response to SARS-CoV-2 infection could open the door to even more effective and powerful vaccines against the coronavirus and its rapidly emerging variants keeping the global pandemic smoldering.

Researchers from Boston University’s National Emerging Infectious Diseases Laboratories (NEIDL) and the Broad Institute of MIT and Harvard say it’s the first real look at exactly what types of “red flags” the human body uses to enlist the help of T cells—killers sent out by the immune system to destroy infected cells. Until now, COVID vaccines have been focused on activating a different type of immune cell, B cells, which are responsible for creating antibodies. Developing vaccines to activate the other arm of the immune system—the T cells—could dramatically increase immunity against coronavirus, and importantly, its variants.

In their findings, published in Cell, the researchers say current vaccines might lack some important bits of viral material capable of triggering a holistic immune response in the human body. Based on the new information, “companies should reevaluate their vaccine designs,” says Mohsan Saeed, a NEIDL virologist and the co-corresponding author of the paper.

Saeed, a BU School of Medicine assistant professor of biochemistry, performed experiments on human cells infected with coronavirus. He isolated and identified those missing pieces of SARS-CoV-2 proteins inside one of the NEIDL’s Biosafety Level 3 (BSL-3) labs. “This was a big undertaking because many research techniques are difficult to adapt for high containment levels [such as BSL-3],” Saeed says. “The overall coronavirus research pipeline we’ve created at the NEIDL, and the support of our entire NEIDL team, has helped us along the way.”

Saeed got involved after he was contacted by genetic sequencing experts at the Broad Institute, computational geneticists Pardis Sabeti and Shira Weingarten-Gabbay. They hoped to identify fragments of SARS-CoV-2 that activate the immune system’s T cells.

“The emergence of viral variants, an active area of research in my lab, is a major concern for vaccine development,” says Sabeti, a leader in the Broad Institute’s Infectious Disease and Microbiome Program. She is also a Harvard University professor of systems biology, organismic and evolutionary biology, and immunology and infectious disease, as well as a Howard Hughes Medical Institute investigator.

“We swung into full action right away because my laboratory had [already] generated human cell lines that could be readily infected with SARS-CoV-2,” Saeed says. The group’s efforts were spearheaded by two members of the Saeed lab: Da-Yuan Chen, a postdoctoral associate, and Hasahn Conway, a lab technician.

From the outset of COVID pandemic in early 2020, scientists around the world knew the identity of 29 proteins produced by SARS-CoV-2 virus in infected cells—viral fragments that now make up the spike protein in some coronavirus vaccines, such as the Moderna, Pfizer-BioNTech, and Johnson & Johnson vaccines. Later, scientists discovered another 23 proteins hidden inside the virus’ genetic sequence; however, the function of these additional proteins was a mystery until now. The new findings of Saeed and his collaborators reveal—unexpectedly and critically—that 25 percent of the viral protein fragments that trigger the human immune system to attack a virus come from these hidden viral proteins.

How exactly does the immune system detect these fragments? Human cells contain molecular “scissors”—called proteases—that, when the cells are invaded, hack off bits of viral proteins produced during infection. Those bits, containing internal proteins exposed by the chopping-up process—like the way the core of an apple is exposed when the fruit is segmented—are then transported to the cell membrane and pushed through special doorways. There, they stick outside the cell acting almost like a hitchhiker, waving down the help of passing T cells. Once T cells notice these viral flags poking through infected cells, they launch an attack and try to eliminate those cells from the body. And this T cell response isn’t insignificant—Saeed says there are links between the strength of this response and whether or not people infected with coronavirus go on to develop serious disease.

“It’s quite remarkable that such a strong immune signature of the virus is coming from regions [of the virus’ genetic sequence] that we were blind to,” says Weingarten-Gabby, the paper’s lead author and postdoctoral fellow in the Sabeti lab. “This is a striking reminder that curiosity-driven research stands at the basis of discoveries that can transform the development of vaccines and therapies.”

“Our discovery … can assist in the development of new vaccines that will mimic more accurately the response of our immune system to the virus,” Sabeti says.

T cells not only destroy infected cells but also memorize the virus’ flags so that they can launch an attack, stronger and faster, the next time the same or a different variant of the virus appears. That’s a crucial advantage, because Saeed and his collaborators say the coronavirus appears to delay the cell’s ability to call in immune help.

“This virus wants to go undetected by the immune system for as long as possible,” Saeed says. “Once it’s noticed by the immune system, it’s going to be eliminated, and it doesn’t want that.”

Based on their findings, Saeed says, a new vaccine recipe, incorporating some of the newly discovered internal proteins making up the SARS-CoV-2 virus, would be effective in stimulating an immune response capable of tackling a wide swath of newly emerging coronavirus variants. And given the speed with which these variants continue to appear around the world, a vaccine that can provide protection against all of them would be a game changer. 

Reference:
 Weingarten-Gabbay S, Klaeger S, Sarkizova S, et al. Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs. Cell. doi: 10.1016/j.cell.2021.05.046.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Best vitamin D supplements UK to boost your immune system

Best vitamin D supplements UK to boost your immune system

  • June 17, 2021
D

idn’t your parents always tell you when you were young to go outside in the sun and soak up some all-important vitamin D? Well, it turns out they might have a point.

Research by the British Nutrition Foundation suggests that across the UK, approximately one in five people have low vitamin D levels. And this has only been worsened by Covid, as people have tended to stay indoors more over the past year.

But why is vitamin D so important? And should we all be supplementing it?

Vitamin D is needed to help regulate the amount of phosphate and calcium in the body in order to keep bones, teeth and muscles healthy, as well as maintaining your immune system. Lack of it can lead to bone deformities such as rickets in children or bone pain due to osteomalacia in adults.

The two most important forms of vitamin D for humans are D2 and D3. Vitamin D2 is made by plants, while D3 (the more important one) is made by the skin when exposed to sunlight.

According to the NHS, from about April to September, most people should be able to get all the vitamin D they need from sunlight. But that doesn’t help for the remaining dark and gloomy half of the year.

Although vitamin D can be found in a small number of foods – including oily fish, red meat and eggs – it is difficult to get sufficient quantities from food alone which is why it is recommended that, for anyone over the age of one, 10 micrograms a day should be supplemented – up to a maximum of 100 micrograms for adults.

Shop the best vitamin D supplements below.

BetterYou D3000 Vitamin D Daily Oral Spray

BetterYou is a product that appears time and time again in health shops, and for good reason.

Their pill-free daily oral spray is extremely easy to use and can by shoved in a bag and taken on the go, without the need for water to wash it down. Its liquid formula is a great option for those who struggle to swallow pills and its subtle minty taste means no bitter flavour is left behind in your mouth. The sprays come in a variety of potencies and include ones specially formulated for vegans, juniors and infants.

If all that wasn’t enough, half of BetterYou’s product range now uses plastic for their packaging that has been collected from the Jakarta and Java Seas – a win on all fronts.

BetterYou

Nature’s Way Alive! Women’s Energy

If you find it a struggle to get your children to eat anything healthy, let alone vitamins, these Alive! vitamin D gummies will be your new best friend.

The bright purple easy-to-chew tablet with a berry citrus flavour means there’s no nasty “medicinal” taste and so makes ensuring children are getting all they goodness they need without a fuss.

Not only that, but these vitamins are stuffed full of 26 fruits and veggies, including cherry and cauliflower, and they are also vegetarian friendly – a double win!

For adults, Nature’s Way also offer high strength vitamin D capsules, which are available in various strengths and flavours.

Nature’s Way

Nourished 3D Printed Vitamins

Want to avoid the faff of having to take multiple vitamins for every aspect of your health? Opt for Nourished. Their 3D-printed vitamins are vegan-friendly and designed by you, to your specification, so you can be sure to get all the nutrients you need.

Whether you’re looking to have more energy, be more focused or get better heart health, build your own custom seven-ingredient stack from 28 nourishments (including ashwagandha, lycopene and vita-algae D3) or take Nourished’s quiz to determine exactly the right combination to help optimise your lifestyle.

You can sign up for just a one-off box of vitamins or they offer a fab subscription service where you can get the box sent directly to your door, so you’ll never need to worry about running out.

As far as vitamins go, they are also the tastiest ones on the market by a long shot. What’s not to love?

Nourished

Voost Vitamin D 25ug

Struggle to swallow pills? Voost takes all the stress out of getting a nutritional boost with their effervescent tablets – just add water.

The sugar-free dissolvable pills offer your daily dose of vitamin D and come in a tasty berry flavour – it’s almost like drinking a soft drink. Voost has a range of different vitamins in 10 and 20-tablet packs, the smaller of which is perfect for taking on the go.

Still not convinced? Research suggests that unlike conventional pills that sometimes only partially dissolve and so can lead to irritation, effervescent tablets dissolve completely so you can be sure you’ll get the maximum benefit.

Voost

Botanycl Vegan Vitamin D3

For those who are looking for the most natural supplement possible, opt for Botanycl. Their plant-based botanical range, which is manufactured in the UK, extends to three products: the skincare elixir, vitamin C and vitamin D3.

Their vegan vitamin D3 comes from lichen, which is the only known plant-based source of vitamin D3 as many others derive from sheep’s wool, and is in a base of high-oleic sunflower oil and coconut oil to allow for superior absorption.

The four-month supply of capsules come in a glass bottle, eliminating plastic waste and meaning the pot is recyclable so you can feel good about the environment while doing good to yourself.

Botanycl

MyVitamins Vitamin D3 Spray

Sports nutrition specialists MyProtein offer a whole range of vitamin D supplements under their sister brand MyVitamins, with products that are uniquely tailored to give an extra boost to active people.

As well as the standard vitamin D3 softgel capsules (in both vegan and regular formulas) and spray, they also have a vitamin D3 and K2 supplement which helps support the immune system and bone health.

For serious sportspeople, the vitamin D3 elite supplement has been tested by Informed-Sport in line with the World Anti-Doping Agency guidelines and declared safe for professional athletes of all levels.

Lastly, their vegetarian curcumin and vitamin D capsules contain all the benefits of vitamin D, along with curcumin – the active ingredient in turmeric which is known for its anti-inflammatory nature – making it perfect for anyone wishing to prevent injuries through sports training.

Myvitamins

Solgar Vitamin D3

Solgar is a great, high-quality product that does exactly what it says on the tin. With 13 vitamin D products alone and a variety of different strengths, formulas and sizes, there’s something for everyone.

For those that need a little extra boost, their “introduction” dose starts at 10 micrograms and is the perfect pick-me-up. Otherwise, if you’re looking for a full-on sunshine soaking, opt for the 100 micrograms.

The range includes softgel, chewable and regular tables, vegetable capsules, as well as a natural orange flavour liquid supplement, so you’re guaranteed to find one that works for you, however you like to take it. All of the above, except the softgels, are also suitable for vegetarians.

Solgar

Cytoplan Vitamin D3 & K2

Cytoplan offers fantastic wholefood, organic and vegan supplements that are both ethically and sustainably sourced. It is worth considering that they are charity-owned, meaning ethical decisions over profit are at the heart of the company, and also every product bought contributes to social change, all of which garners them serious plus points.

Their vegan vitamin D3 pills also contain K2, as the vitamins work synergistically so taking both helps to ensure optimum biological activity. Or, if tablets aren’t for you, they also do vegan vitamin D3 drops, as well as supplements tailored to juniors.

With Cytoplan, feeling good and doing good has never been so simple.

Cytoplan

Vitabiotics Vitamin D

Chances are you’ve already heard of Britain’s number one vitamin company, so I’ll save the introduction.

All you need to know is that their British Pharmacopoeia-quality (that’s the quality standards for UK medicinal products, to you and me) vitamin D tablets are free from artificial preservatives, colours, yeast and lactose and are also suitable for vegetarians.

Their tablets are very small and so easy to for even those that struggle to swallow, and they come in a variety of different strengths, from everyday to maximum. However, if tablets really aren’t an option for you, they also do vitamin D gummies, drops for babies and jellies for children.

Vitabiotics

Verdict

For their fret-free application and ease of portability, BetterYou’s daily oral vitamin D spray ticks all of the boxes when it comes to simple supplementing. The large range of strengths, as well as both adult and children formulas, also means there is something suitable for everyone.

Andrew Wang, MD/PhD, AB, Assistant Professor of Medicine (Rheumatology) and Immunobiology

Andrew Wang, MD/PhD, AB, Assistant Professor of Medicine (Rheumatology) and Immunobiology

  • June 17, 2021

By Saphia Suarez

For Andrew Wang, MD/PhD, AB, his interest in inflammation biology started at home. “My mom has lupus, which is an autoimmune disease that causes the immune system to attack its own organs,” said Wang, assistant professor of medicine (rheumatology) and immunobiology. “So I spent a lot of my childhood accompanying her to the doctor. Then in high school biology, I learned the immune system is the one example where the one gene to RNA to protein rule does not hold. Out of a set of finite genes, our immune system can make an infinite number of proteins to protect us from things we’ve never seen. And that was just so intellectually addictive. So in high school I started researching inflammation biology, which I continued at Harvard through my undergraduate and PhD. And then I became a rheumatologist, so now I treat patients with the same condition as my mom.”

Wang came to Yale in 2011 to complete his internship, residency, fellowship, and post-doctoral training under the mentorship of Ruslan Medzhitov, PhD, Sterling Professor of Immunobiology, one of the foremost thinkers in inflammation biology. “I came to Yale for him,” said Wang. “I met him here when I was interviewing for the Physician Scientist Training Programs, and we really hit it off. Then I did my postdoc in his lab, and he continues to be the major mentor and father figure in my life now. He is the living definition of a true mentor.”

It was in Medzhitov’s lab that Wang became interested in behavioral responses to inflammation. “One of the major projects in his lab was essentially figuring out why my mom always told me to starve a fever and feed a cold,” said Wang. “I think many people have similar conventional wisdom given to them. And so we made the astonishing observation that it wasn’t only that animals didn’t eat when sick, but that what you fed them made a big difference depending on what type of infection they had.”

Wang discovered that in mice, sugar-containing foods offered protection from viral infections, but were deadly for mice with bacterial infections. “We identified that metabolic programs in an animal are tied to the type of inflammation that they need to defend against certain types of infection,” said Wang. “I spent about three years trying to decode those programs. This has a lot of clinical implications, because right now we don’t adjust feeding based on type of infection.”

Wang now has his own lab, and is currently working on identifying host environment interactions that impact inflammation response. The first paper out of his lab was published in Cell in 2020. “We found a mechanistic explanation for why increased psychosocial stress is a good thing when you’re trying to run away from a lion, which is how we evolved to have this stress response. But there’s a cost for this, which is that if you experience inflammation, you may not tolerate that well. Which makes sense—there’s usually a cost for most things that we have to do.”

Wang is now exploring the experimental oddity called lethal dose 50. “Lethal dose 50 occurs when you give genetically identical mice living in the same conditions the same dose of something and half of them die. And it turns out that this is a related phenomenon to diseases like lupus, where if you have genetically identical twins and they live in the same conditions with the same characteristics, only about 40% of the time at best will both twins develop the same disease. This goes back to nature versus nurture, and how much of biology is truly random. We don’t respond to stress in the same way. Those are not things that are entirely genetically encoded, they’re encoded within social structures. So we normalized all these different micro-environmental changes and found a big effect size in psychosocial stress. The lethal dose 50 effect went away, and mortality increased to 100%. In other words, stress kills.”

Wang is looking at the connection between preceding stress and autoimmune flareups. “We are interested in the mind-body connection,” said Wang. “So, how does preceding stress lead to actual physiological changes, like a lupus flare?” Wang knows it starts in the environment. For patients with autoimmune diseases, flares in the disease correlate to environmental stressors, such as major life events. “We don’t know what in the environment matters,” said Wang. “There are a lot of diseases that are much more common now in the modern environment than even 50 years ago. So we are essentially trying to sort out the dark matter within this new modern environment.”

Looking forward, Wang is hoping to explore placebo and nocebo effects. “In most clinical trials, there’s always a placebo group and there’s always a response in that group, often around 20 or 30%. So how does that work? Because if we could figure that out, we could boost drug responses across the board and leverage placebo biology to improve the effect size of therapy. And likewise, can we use nocebo biology—which is when you perceive that something will make you worse and it does—to prevent the failure of certain treatment responses? This could have large implications for inflammation biology, because the observation we made that stress makes inflammation worse is essentially one version of nocebo.”

The Section of Rheumatology, Allergy and Immunology is dedicated to providing care for patients with rheumatic, allergic and immunologic disorders; educating future generations of thought leaders in the field; and conducting research into fundamental questions of autoimmunity and immunology. To learn more about their work, visit Rheumatology, Allergy & Immunology.

Immune system dysfunction can alter the link between cannabis use and psychosis

Immune system dysfunction can alter the link between cannabis use and psychosis

  • June 17, 2021

The presence of pro-inflammatory cytokines in the blood can boost the effects of daily cannabis use and heighten the risk of developing psychosis in adulthood. Similar results have been observed, also in the presence of cytokines, when cannabis is used during adolescence. Psychotic disorders have symptoms such as delirium, loss of a sense of reality, hallucinations, hearing voices, and cognitive and social impairments.

A study by researchers at the University of São Paulo’s Ribeirão Preto Medical School (FMRP-USP) in Brazil, reported in an article in the journal Psychological Medicine, finds for the first time that individuals exposed to a combination of these two factors – the presence of pro-inflammatory cytokines in the blood and cannabis use (either daily or during adolescence) – are more likely to suffer from psychosis than those who are exposed to neither or to only one. According to the authors, the study provides “the first clinical evidence that immune dysregulation modifies the cannabis-psychosis association”.

The study was part of a project conducted by the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI), a consortium of research centers in 13 countries, including Brazil. An article published in The Lancet Psychiatry by the consortium in 2019 showed that daily cannabis use increased the likelihood of suffering from a psychotic disorder threefold.

In the more recent study, the researchers analyzed data for 409 people aged 16-64, including patients experiencing their first psychotic episode and community-based controls. The sample was drawn from the populations of Ribeirão Preto and 25 other cities in the region. The variables analyzed included cannabis use frequency (daily, not daily or never), duration (five years or less), and onset age (in adolescence or later).

In addition to the questionnaire on cannabis use, the researchers measured various cytokines in plasma donated by the volunteers and calculated scores representing their systemic inflammatory profiles. They also collected clinical and socio-demographic data, especially variables known as confounders, such as age, gender, schooling, ethnicity, body mass index, smoking, and use of psychoactive substances. The results obtained were independent of confounding factors.

Not everyone who uses cannabis develops psychosis. This suggests that the association may be modified by other factors, which may be biological, genetic or environmental. In a previous study conducted as part of my master’s research, we identified a correlation between plasma cytokines and the first psychotic episode. Following up on this discovery, and the consortium’s recent publication showing a higher incidence of psychosis among subjects who used cannabis on a daily basis, our next step was to see if the biological factor [inflammatory profile] affected the link between cannabis use and psychosis.”


Fabiana Corsi-Zuelli, First Author of the Article

The main conclusion was that such a link did indeed exist. “We found a statistically significant correlation between inflammatory profile and cannabis use on a daily basis or during adolescence. In sum, the results showed that immune system dysfunction can modify the association between cannabis use and psychosis and that a combination of these two factors increases the odds of suffering from a psychotic disorder,” she said.

Corsi-Zuelli is currently a PhD candidate in FMRP-USP’s graduate program in neurology and neurosciences, with support from São Paulo Research Foundation – FAPESP.

The principal investigator for the project is Cristina Marta Del-Ben, a professor at FMRP-USP’s Department of Neurosciences and Behavioral Sciences. According to Del-Ben, risk factors for psychosis may be biological, including genetic predisposition and problems during pregnancy, as well as environmental, including traumatic experiences during childhood and adolescence, and exposure to psychoactive substances, especially cannabis.

“The mechanisms of the disorder are poorly understood,” she said. “Our findings show that frequent current use of cannabis or use of the drug in adolescence is a risk factor for psychosis. We didn’t detect the same correlation with occasional or recreational use. In the multicenter study, which included European cities with varying levels and types of cannabis availability, we also found that the risk of psychosis is greater in users of stronger cannabis strains with a THC content or 10% of higher.” THC (delta-9-tetrahydrocannabinol) is the primary psychoactive constituent of cannabis or marijuana.

The medical explanation of psychosis is that it is a neuropsychiatric syndrome associated with anatomical and functional alterations in the brain, possibly linked to changes in the action of dopamine, a key neurotransmitter for communication among neurons. Excessive dopamine or direct damage to certain brain regions can lead to hallucinations, delusions, delirium and disorganized behavior.

Other neurotransmitters, such as glutamate, have also been implicated in the neurobiology of psychosis. Specialists are currently discussing what they call the neuroimmune link, and how immune system dysregulation may trigger neurochemical, morphological and behavioral alterations that heighten the risk of developing psychiatric disorders.

Psychotic symptoms may be present in several psychiatric disorders, which may or may not be affective. Recent research has taken note of cases of psychosis in patients infected by SARS-CoV-2. Treatment of psychosis involves a combination of medication, psychotherapy and family support.

Next steps

According to Corsi-Zuelli, the origin of the inflammatory alterations involved in psychosis is still obscure, but it may arise from a combination of genetic and environmental factors. “The inflammation seen in psychiatric disorders is considered low-level and isn’t as severe as in patients with autoimmune diseases or sepsis,” she said. “Nevertheless, experimental studies suggest it entails sufficient dysregulation to produce neurochemical and behavioral alterations.”

The researchers plan next to study genetic variants associated with the immune system and use neuroimaging data to explore the link with environmental risk factors. “Focusing in this way on the interactions between genetics and the environment will help us understand the neurobiology of psychosis, especially the role played by the immune system,” she said.

The association between inflammation and psychiatric disorders is highly relevant to clinical practice and has received growing attention. “It’s important to the search for alternative treatments for these disorders, and also to answering often neglected questions relating to the physical health of psychiatric patients,” Corsi-Zuelli said.

According to Del-Ben, in the pipeline for next steps is a partnership with Geraldo Busatto Filho, a professor at the Medical School (FM) in USP’s main campus, to investigate whether inflammatory markers in blood are linked to brain alterations in some of the patients studied.

The research has twice received international recognition. The Society of Biological Psychiatry selected the study for its Predoctoral Scholars Award, which was to have been formalized at SOBP’s 2020 annual meeting in New York, but the pandemic forced a postponement until April 2021, when the meeting was held online. And the study was selected by the Schizophrenia International Research Society (SIRS) for presentation at its 2020 Congress, also held online.urce:

Eat jackfruit to strengthen immune system 

Eat jackfruit to strengthen immune system 

  • June 17, 2021

Amid the ongoing Covid-19 crisis, people are making several efforts to improve their immunity. There is no better way to strengthen the immune system than through a healthy diet. Eating nutritious food daily is the easiest way to build immunity naturally. There are many types of food rich in essential micronutrients. You can easily include them in diet and one of them is jackfruit and jackfruit nuts.

Benefits of delicious summer fruit 

Sweet-smelling, succulent summer fruit can be eaten either raw or cooked. Most people prefer the fleshy fruit and discard the hard nut-like seeds. Perhaps they do not know that nutrients can also be found in seeds which can help in increasing immunity. Eating a variety of food and leading a disciplined lifestyle is the foundation of immunity building. The powerful seeds of jackfruit can be cooked or you can roast it with a little salt and chilli. Using it as a snack will prove beneficial for you. Rich in a variety of nutrients, this fruit can help you in many ways. This will add variety to your diet while strengthening your immunity.

Immunity 

Jackfruit is not only rich in protein but a small amount of fat can also be found. In addition to the antioxidants present in the yellow fruit, vitamins A and C can prevent many diseases. Eating this fruit regularly can also reduce the risk of viral infection. Vitamin C can help in prevention of inflammation and may reduce the risk of chronic diseases such as heart disease and cancer. Carotenoids and flavonoids, two major antioxidants, may help reduce the risk of inflammation, type 2 diabetes, heart disease and high blood pressure.

Other benefits of jackfruit 

The yellow fruit of summer can also work to improve skin and wrinkles. The antioxidants present in it can protect you from inflammation and oxidative stress. Jackfruit is also used in many places in the treatment of asthma, diarrhoea and stomach ulcers.

3 COVID shots could boost immunity in solid organ transplant recipients

3 COVID shots could boost immunity in solid organ transplant recipients

  • June 17, 2021

BIRMINGHAM, Ala. (WBRC) – New research from Johns Hopkins University Hospital shows a third dose of the COVID-19 vaccine could be a way to improve immunity in immunocompromised patients, especially for organ transplant recipients.

Health experts said solid organ transplant recipients tend to have weakened immune systems.

“When you have an organ transplant, you get put on very powerful drugs to suppress your immune system because it’s your immune system that can otherwise lead you to reject those organs that you’ve received, and therefore when they’re given a vaccination, the vaccine doesn’t induce immunity. It doesn’t create an immune response,” said State Health Officer for the Alabama Department of Public Health, Dr. Scott Harris.

But a new study from Johns Hopkins University Hospital shows a third dose of the COVID-19 vaccine could improve immunity response in these groups.

“We’ve had these people with immune system problems like organ transplant patients who are allowed to take a vaccine, but whom we really didn’t expect the vaccine to work, and so, it’s encouraging to that perhaps there is a way to induce immunity in these patients,” Dr. Harris said.

The study followed 30 solid organ transplant recipients.

Almost all of them had low or no immunity to the vaccine.

But after a third shot, 33% of patients with no immunity, and 100% of patients with low immunity, increased their antibody levels.

“We also know that because of their medical conditions, in many cases, they’re at even more risk of serious illness if they do get COVID compared with the average person. We want to protect them even more, in a way, than the average person. So, it’s encouraging to think that we may have a way to do that,” Dr. Harris said.

Health experts said this 30-patient study isn’t big enough to be a formal patient trial, but it’s enough preliminary data to show promise in future studies.

They still recommend organ transplant recipients get the vaccine, but still take precautionary measures to ensure protection.

Copyright 2021 WBRC. All rights reserved.

Jeannie Baumann

NIH Chief Mulls ‘Precision’ Booster Shots Against Covid-19

  • June 16, 2021

Advances in precision medicine may help transform Covid-19 booster shots from a community-wide effort to one that’s tailored to individual immune responses.

There’s no conclusive data that follow-up vaccinations will be necessary, but Pfizer Inc. and Moderna Inc. are studying the issue to stay ahead of variants. A key element that vaccine makers will need to pinpoint is the specific measurable marker in the immune system—called correlates of protections—that determines if a vaccine is still providing protection.

“It’s going to be really interesting, because we’re all different people,” Francis S. Collins, director of the National Institutes of Health, said Wednesday at the Biotechnology Innovation Organization’s annual conference.

“Those experiments are getting done right now for the Moderna and the Pfizer trial. So we’ll know pretty soon what is thought to be the most reliable correlate,” he said.

Traditionally, the need for booster shots stems from an evaluation of aggregate data to determine when the level of protection has waned to the point where additional vaccinations are necessary.

“But we’re pretty good now at switching from one-size-fits-all to individual information, what I might call precision medicine,” Collins said. “Do we need precision boosters, to basically have some individual analysis of your immune response to say whether it’s ready for a boost or whether you can take your time?”

He added that precision boosters “is potentially going to be part of the answer this time, but it hasn’t been before.”

It’s unclear whether the NIH is funding research on precision boosters for Covid-19 vaccines specifically. But research to apply precision medicine to vaccinations is ongoing. Boston Children’s Hospital has a precision vaccines program to classify individuals into subgroups based on how likely they are to contract certain diseases and how likely they are to benefit from vaccination.

Virus Variants

Antibodies levels appear to protect both against the original coronavirus strain and the variants six to eight months after the original vaccination, based on evaluation of clinical trial participants.

“That’s the good news. But the bad news is they are trending down,” Collins said.

The mRNA vaccines by Pfizer and Moderna appear to offer protection against the known variants of concern, although that level of protection may be somewhat diminished. Public health leaders have urged people to get both doses of the vaccine as quickly as possible both to protect themselves, their communities, and to help stop the spread of variants.

Pfizer CEO Albert Bourla has said a booster may be necessary between eight and 12 months after receiving the second dose of the Pfizer-BioNTech vaccine. Early results from a Moderna study released last month indicated a booster shot the company developed appears to protect against the Beta variant, which was first identified in South Africa.

Anthony S. Fauci, director of the NIH’s National Institute of Allergy and Infectious Diseases, said at a White House press briefing recently the agency is studying both variant-specific boosters and boosting against the wild type, which is the background strain that contains no major mutations.

“The higher your degree of immune response against the wild-type, the greater the secondary coverage you have against a wide array of variants,” Fauci said. “When you look at particularly the double doses—primary and boost of the mRNA vaccines, which we have the most data—there is rather good protection that spills over against multiple variants.”

Vitamin D and COVID-19: What to Know

Nandrolone: What to Know

  • June 16, 2021

What Is Nandrolone?

Nandrolone is a type of anabolic steroid. Anabolic steroids include testosterone and lab-grown (synthetic) forms of testosterone. Doctors prescribe anabolic steroids, including nandrolone, to treat some illnesses and injuries.

Some athletes — professionals as well as everyday athletes and even adolescents — misuse steroids like nandrolone to build muscle and boost performance.

But studies show that overuse or misuse of nandrolone or any other anabolic steroid could be bad or dangerous for your health. That’s why it’s so important to use the drug only by prescription and under a doctor’s care.

What Is Nandrolone Used For?

Doctors sometimes prescribe nandrolone for illnesses and injuries including:

  • Burns
  • Allergic reactions
  • Eye injuries, especially to the cornea
  • Brittle bones (osteoporosis)
  • Body wasting (cachexia)
  • Anemia from cancer
  • Appetite loss from cancer
  • Prostate and breast cancers

Steroids help healing, in part, because they lessen the activity of the immune system. Your body fights infection and germs with white blood cells and other chemicals that can lead to inflammation. By reducing this immune activity, steroids can lessen inflammation and tissue damage, as well. The downside is that it can raise your risk of infection.

If they need to give you nandrolone, your doctor will prescribe a dose that’s safe and appropriate for your condition. Make sure they know about any other medicines you’re taking, including steroids, and whether you’ve used them before.

How Do People Misuse Nandrolone?

Misuse usually starts with a purpose — most often to help athletes build muscle or improve performance. But the FDA has not approved nandrolone to enhance athletic performance. Because of the serious health risks, most sports organizations have banned anabolic steroids like nandrolone.

In addition, nandrolone is a Schedule III controlled substance under federal law. That means it carries a risk of abuse and addiction. It also means that misuse can be a federal offense, punishable by hefty fines and even prison time.

Even the typical prescribed dose of nandrolone for an illness or injury (about 0.4 milligrams per kilogram of body weight a day) can have side effects like headaches, bloating, diarrhea, belly pain, jaundice, high blood pressure, and changes in menstrual cycle. Athletes often use 10 times this amount or more to boost muscle mass or performance. That can lead to even more serious effects.

People who misuse anabolic steroids like nandrolone may swallow them or rub them into their skin. But the most common way to use nandrolone is to inject it into a muscle.

What Happens When You Misuse Nandrolone?

Some of the most serious effects seem to be in the liver, where tumors may grow, and on the endocrine system, the complex system of glands that make the hormones that control your breathing, digestion, growth, and reproduction, among other things.

Symptoms of misuse include:

Some of these problems may go away when you stop taking nandrolone, but others could last a long time. There’s even some evidence that nandrolone could promote the growth of cancer in certain cases.

If you’re concerned about your health, your fitness, or your body image, talk to your doctor about healthy ways to improve them. A certified personal trainer may also be able to help.

Can Testing Show a ‘False Positive’ for Nandrolone?

Because of the widespread use of nandrolone among professional athletes, the governing bodies of many sports require testing. Some whose tests have found nandrolone have claimed that it’s a “false positive.” This is a possibility for a number of complex reasons.

One explanation has been “it must have been something I ate.” There is some science behind the claim: Studies in 2000 and 2001 showed that people who ate certain kinds of pork (specifically, from an uncastrated male boar) had enough nandrolone in their urine to raise questions about whether they had misused the drug, even though they hadn’t.

capsimmunesystem.org