New Jersey is 4th Best State in America for Police Officers

New Jersey is 4th Best State in America for Police Officers

  • May 22, 2020

The Coronavirus Crisis in America has brought a whole new aspect to the daily work of our Police. Not only around the nation but right here in New Jersey.

According to a new survey by Wallethub, police in New Jersey rank 4th in the nation and that’s a good thing for our men and women in blue.

Here are some of the findings and national rankings for Police with life and work in New Jersey:

  • 6th – Law-Enforcement Officers per Capita
  • 2nd – Median Income for Law-Enforcement Officers (Adjusted for Cost of Living)
  • 29th – Median Income Growth for Law-Enforcement Officers
  • 6th – Violent-Crime Rate
  • 10th – State & Local Police-Protection Expenses per Capita
  • 12th – Police Deaths per 1,000 Officer

We THANK  our local police and all they are doing for us amidst the COVID-19 Crisis.

Here are the national Top 5 rankings:

  • Connecticut
  • North Dakota
  • New York
  • New Jersey
  • Minnesota

 

 

Coronavirtus: Immune clue sparks treatment hope

Coronavirtus: Immune clue sparks treatment hope

  • May 22, 2020

Blood samples

Image copyright
Getty Images

UK scientists are to begin testing a treatment that it is hoped could counter the effects of Covid-19 in the most seriously ill patients.

It has been found those with the most severe form of the disease have extremely low numbers of an immune cell called a T-cell.

T-cells clear infection from the body.

The clinical trial will evaluate if a drug called interleukin 7, known to boost T-cell numbers, can aid patients’ recovery.

It involves scientists from the Francis Crick Institute, King’s College London and Guy’s and St Thomas’ Hospital.

They have looked at immune cells in the blood of 60 Covid-19 patients and found an apparent crash in the numbers of T-cells.

Prof Adrian Hayday from the Crick Institute said it was a “great surprise” to see what was happening with the immune cells.

“They’re trying to protect us, but the virus seems to be doing something that’s pulling the rug from under them, because their numbers have declined dramatically.

In a microlitre (0.001ml) drop of blood, normal healthy adults have between 2,000 and 4,000 T-cells, also called T lymphocytes.

The Covid patients the team tested had between 200-1,200.

‘Extremely encouraging’

The researchers say these findings pave the way for them to develop a “fingerprint test” to check the levels of T-cells in the blood which could provide early indications of who might go on to develop more severe disease.

But it also provides the possibility for a specific treatment to reverse that immune cell decline.

Manu Shankar-Hari, a critical care consultant at Guy’s and St Thomas’ Hospital, said that around 70% of patients that he sees in intensive care with Covid-19 arrive with between 400-800 lymphocytes per microlitre. “When they start to recover, their lymphocyte level also starts to go back up,” he added.

Interleukin 7 has already been tested in a small group of patients and proved to safely increase the production of these specific cells.

In this trial, it will be given patients with a low lymphocyte count who have been in critical care for more than three days.

Mr Shankar-Hari said: “We are hoping that [when we increase the cell count] the viral infections gets cleared.

“As a critical care physician, I look after patients are extremely unwell and, other than supportive care, we do not have any direct active treatment against the disease.

“So a treatment like this coming along for in the context of a clinical trial is extremely encouraging for critical care physicians across the UK.”

This research has also provided insight into the specific ways in which this disease interacts with the immune system, which Prof Hayday says will be vital as scientists around the world look for clinically valuable information.

“The virus that has caused this completely Earth-changing emergency is unique – it’s different. It is something unprecedented.”

“The exact reason for this disruption – the spanner in the works of the T-cell system – is not at all clear to us.

“This virus is really doing something distinct and future research – which we will start immediately – needs to find out the mechanism by which this virus is having these effects.”

Hang Your Quilts Day

May 29 | Free Guided Meditation for Relaxation & boosting Immune System

  • May 22, 2020

Hello Neighbors,

As the COVID-19 shelter-in-place order has expanded to end of May, the stress levels may still be on the rise compared to normal days.

In order for us and for our family to stay healthy, it is important for us to keep calm, and strengthen our immune system.

I would like to share with you a guided meditation for relaxation and for mental boosting of the immune system, you can listen to at ANY TIME throughout the month any beyond, from the comfort of your HOME.

I wrote and recorded this meditation with love, to support our community in this time of uncertainty.

I invite you: women, men, and children who would like to join me, to allow yourself some me-time to relax and stay strong from the inside out.

Guided Meditation for Relaxation and Mental boost for Immune System

And if you liked this recording, please spread the good and Share it with anyone who may benefit from it too.

Please feel free to contact me via: connect@myDesiredOutcome.com if you have any questions, or requests,

Also, if you need some personal guidance,
feel free to schedule your free 15 min consultation (video) call with me through my web site.

Stay Safe and Healthy,

Love,

Michelle Guelfand
Holistic Life Coaching, Lectures & Seminars
www.myDesiredOutcome.com

Churches Plan to Defy Executive Order, Reopen Early

Churches Plan to Defy Executive Order, Reopen Early

  • May 22, 2020

UNDATED — Two religious organizations in Minnesota say they will defy current executive orders and resume full worship services next week.

The Minnesota Catholic Conference and The Lutheran Church–Missouri Synod sent letters to Governor Tim Walz and Attorney General Keith Ellison Wednesday, announcing their intentions to hold regular worship services beginning May 26. The move comes despite Minnesota’s current COVID-19 executive order capping indoor religious gatherings at 10 people.

The Becket Fund for Religious Liberty, representing the two organizations, argues that keeping churches closed is in violation of the First Amendment.

“If malls, casinos, liquor stores, bars, and restaurants are reopening, why can’t Minnesota churches?” said Becket VP Eric Rassbach. “Our Constitution stands for ‘equal justice under law’ and imposing a special disability on churches is anything but.”

A variety of Minnesota businesses, including retailers and malls, reopened Monday under certain conditions. There has been no timeline provided by Gov. Walz on when regular, in-person religious services will be allowed to resume.

Building a Better Immune System

Building a Better Immune System

  • May 22, 2020

Colorful fruits and vegetables—and easy-to-get vitamin D—can help you ward off illness

Physicians have often turned to food ingredients to help keep everyone’s immune system as healthy as possible.

Although not a proven cure, doctors in the 1400s recommended their patients include horseradish, mint, vinegar, and applesauce in their diets to ward off the bubonic plague. These ingredients do have some immune-boosting properties, including vitamin C, antioxidants, flavonoids, fiber, and water. Perhaps this is the origin of “an apple a day?”

In the 1600s, Parisian citizens’ thirst for lemonade may have helped to keep the plague out of their city. Lemonade was all the rage; mobile lemonade vendors circulated around the city, dispensing the popular beverage and discarding the citrus peels in the streets. The vitamin C, minerals, and water in the lemonade may have helped to keep the immune system healthy. Plague was spread by fleas from infected rodents. An unintended but helpful consequence was the insect-repelling properties of citrus peels.

Populations that had access to a variety of healthy foods did better during times of widespread disease. People’s diets assisted in building and maintaining healthy immune systems. Until recently, food intake was largely grain-based for many parts of the population, with fruit, vegetables, and meat considered to be “luxury foods.”

Information taken from interviews with survivors of the 1918 flu pandemic showed that people who had regular access to fresh fruits and vegetables, dairy, and protein foods, such as meat, eggs, seafood, or poultry, tended to fare better with recovery from the flu than those with a more restricted diet.

One survivor, interviewed when he was 100 years old, said: “My parents worked for a merchant family in Boston. There were always bananas, oranges, pineapples, and other types of ‘exotic’ fruit in their home, something unheard of at that time. We children were given the pick of one piece of fresh fruit a day; none of us got sick during the epidemic, and we all lived to be at least in our 90s.”

Healthy Choices, Healthy Immunity

Fast forward to today and our widely available assortment of fresh, frozen, canned, and dried immune-building food ingredients. According to Kathleen Zelman, dietitian and director of nutrition for WebMD, we should regularly eat berries, fatty fish, dark green leafy vegetables, whole grains, sweet potatoes, tomatoes, beans, nuts, and eggs for immune system support.

Fresh and dried herbs have been used in the kitchen forever, adding wonderful flavor, color, and health benefits to the foods we eat.

The digestive system plays an important role in immunity. It extracts vitamins and nutrients essential for creating different immune cells and fueling (or suppressing) our immune response. Eating poorly can also undermine immunity, such as sugar’s role in suppressing certain immune responses.

We should try to keep our digestive system as healthy as possible so it can assist with a healthy immune response. Rosemary, with aromatic leaves and flowers, is a natural antioxidant and can have an antibacterial effect on food, helping with digestive health.

Fresh chilies, cayenne, and bell peppers get their “heat” from a natural compound called capsaicin. Capsaicin was found to assist in maintaining stomach health, among several other benefits, according to a review of 78 studies published in Open Heart in 2015. Chopped fresh, frozen, or canned peppers add flavor and increase the health quotient of sauces, pasta, rice, and salads.

The Physician’s Committee for Responsible Medicine reminds us that the more fresh or frozen fruits and vegetables included in a dish, the more immune-enhancing ingredients we put on the plate.

Even without a nutritional analysis, we know that an eggplant stew with tomatoes, summer squash, garlic, onions, carrots, celery, and basil is providing immune benefits in addition to the pleasure of eating great-tasting food. Spinach fettuccini with a mushroom sauce, served with a red and green cabbage salad and fresh melon is filled with immune-enhancing ingredients, beautiful to the eye and satisfying to eat.

If you would like to obtain a fast nutritional analysis for your menu items, you can input ingredients into the USDA’s nutritional data bank online.

Chicken Soup for the Immune System

Most cultures have their version of Grandma’s chicken soup. In Greece, it’s avgolemono (chicken, rice, and lemon soup). In Iran, it’s Persian gundi (chicken meatball soup), and in Puerto Rico, it’s sancocho (chicken and root vegetable soup), while Peru has a chicken, hard-cooked egg, and noodle breakfast soup.

Science has confirmed the health benefits contained in this comforting meal, which help to bolster the immune system. But it’s not all about the chicken. The hot broth, carrots, onions, parsnips, dill, parsley, ground pepper, and additional herbs, veggies, and protein also play a role in flu-fighting.

From Scratch or Speed-Scratch

Homemade soup is an efficient and economical way to include lots of immune bolstering ingredients in one bowl. Peel and chop root vegetables, such as carrots, turnips, parsnips, sweet potatoes, or yellow, gold, or purple potatoes, add a small amount of canned broth or water, and let simmer in a pot or slow cooker until the vegetables are soft.

Puree all or most of the soup, reheat, and serve with a splash of vinegar, lemon, or lime juice or tomato paste. Leftover cooked or canned poultry, bacon, pasta, or tofu can be stirred into the soup for added protein and texture.

If you have the time, make some onion soup. Onions contain vitamin C and flavonoids, known to help with healthy immune reactions. Slice lots and lots of onions, spray a large pot with vegetable oil and quickly stir and sauté. The onions will create their own “juice.” When the onions have gotten very soft, add in vegetable or mushroom broth, allow to simmer, and, voila, onion soup.

If you don’t feel the urge to create “from scratch” soups, here are some ideas for “speed scratch” soups:

Split Pea and Lentil: Add cooked or canned drained lentils to canned split pea soup and dilute according to package directions. Add chopped onions and shredded ham, chopped hot dogs, cubed smoked tofu, or smoked turkey during cooking for more flavor.

Fast Fish Chowder: Thaw and chop frozen fish filets. Simmer with a small amount of broth and chopped carrots, celery, and onions. Add to canned cream of potato or cream of celery soup and allow to cook until hot and veggies are soft. Serve hot with cornbread muffins on the side.

Puree Mongole: A classic soup combination of tomatoes and split peas. Combine canned tomato soup and canned split pea soup with drained, chopped canned tomatoes, cook and stir until hot. Pair with crusty baked bread or herbed breadsticks.

Tomato-Corn Chowder: Combine canned tomato soup with canned corn chowder; dilute with milk, silken tofu, or a combination of plain yogurt and water. Add drained, chopped tomatoes and frozen or canned cut corn (drained) for extra texture. Pair with a small Caesar salad.

Putting the Chill on Soup

We can plan on chilled soups when the weather is warm. Chilled soups can be refreshing and luxurious, and easy to prepare when we don’t want to heat up the kitchen.

Traditional gazpacho has a tomato base. White gazpacho is popular and can have corn and zucchini or tofu base. Green gazpacho is a wonderful way to drink your greens. Create your red gazpacho base by pureeing tomatoes in a blender or food processor with sweet onions, fresh garlic, fresh parsley or basil, and a small amount of oil.

Create your white gazpacho base by pureeing fresh, steamed and chilled or frozen, thawed zucchini with some canned creamed corn (the “cream” is cornstarch, rather than dairy) and a small amount of silken tofu or plain yogurt.

Create your green gazpacho base by pureeing your fresh greens of choice; spinach, kale, and so on. Romaine lettuce and Swiss chard work well. Add a small amount of prepared pesto sauce. Once you have your base, you can add shredded fresh vegetables, fresh herbs, and seasonings to taste. If you’d like thicker gazpacho, crumble some fresh, crustless bread into the mix, blend, and allow to sit. The bread will create a thickened, smooth texture.

Create a pumpkin base for a cold soup by blending canned, unseasoned pumpkin with a very small amount of coconut milk. Cold pumpkin soup can be flavored with curry, pureed carrot, leftover mashed potatoes, orange or lemon zest, or pureed beans. Garnish with frozen grapes or chilled bell pepper slices.

Create a tofu base for a cold soup by blending silken tofu with fresh parsley, sweet onions, a small amount of tomato puree, garlic, onion powder, and white pepper.

Create cold potato chowder by adding cubed, leftover potatoes and mixed veggies, or shredded raw veggies to the tofu base.

Create a cold borscht by pureeing shredded fresh beets or drained, canned beets with the base. You can also create a Thai-inspired cold soup with lemongrass, orange zest, and fresh ginger, or a pesto-cream by blending with prepared pesto and cooked beans.

Balance and Sunshine

Spending time in the kitchen, at the stove, and at the table is a wonderful way to use part of our day. Getting out into the sunshine should also be on our daily “to do” list.

Starting with the advent of television, many children got accustomed to hearing “go outside for a while, you shouldn’t stay in all day.” There is some science behind this directive. In the late 1800s, children living in the sun-limited cities of Northern Europe and North America had a high incidence of developing rickets, a disease caused by vitamin D deficiency. They also had a tendency to contract tuberculosis (TB). Vitamin D was thought to assist the body in warding off TB, and we know it’s critical to helping our immune system differentiate disease-causing cells from healthy cells.

Sunshine is the best source of vitamin D, as the body is able to use UV light from the sun to create vitamin D in the body. According to the National Institutes of Health, UV light plays an important role in many of the body’s immune responses.

Human skin produces beta-endorphins when exposed to UVB.  These opioid peptides boost the immune system, relieve pain, and help us relax and feel well.

Endorphins are “feel-good” chemicals produced by the body, our own personal “cheerleaders.” Sunshine and exercise have been found to assist the body in producing endorphins. We should consider the wisdom of “going outside for a while,” without excessive sun exposure, to help boost our immune system and our spirits.

As the days grow longer and seasonal fruits and vegetables become more available, it’s a good time of year to get plenty of sun and the fresh fruits and vegetables that can get our immune system in shape for the coming cold season.

Dr. Nancy Berkoff is an international nutritionist, food technologist, and culinary professional. She divides her time between health care and culinary consulting, food writing, and healthy living.

#CoronaCurious: Nutritional recommendations to boost the immune system of frontline workers | FIU News

#CoronaCurious: Nutritional recommendations to boost the immune system of frontline workers | FIU News

  • May 21, 2020

Cristina Palacios—associate professor in the Department of Dietetics and Nutrition at the Robert Stempel College of Public Health & Social Work—and a team of international experts recently released a nutritional guide for the Latin American Society of Nutrition (SLAN) that offers recommendations to frontline workers on how to boost their immune systems during the COVID-19 pandemic.

“Frontline workers, whether they are health care workers or essential personnel in other industries that are helping our communities stay afloat, are putting their health a risk, and I hope that with these recommendations, we can at least help guide them to be safer,” Palacios said.

FIU News asked Palacios for tips that could help anyone who is at risk of coming into contact with the virus.

What are the nutritional concerns for frontline workers?

This group of workers may have nutritional insufficiencies due to long hours of work, lack of sleep, high stress, poor diet, dehydration, low sun exposure, among other conditions that may affect their nutritional status. We worked on a set of nutritional recommendations to help strengthen their immune system through supplements, in cases of strong research evidence, or foods, in cases of less evidence.

What is the role of nutrition and diet in trying to stay healthy during COVID-19?

The immune system needs multiple nutrients, such as vitamins and minerals, and certain bioactive compounds, such as omega 3 fatty acids, polyphenols, probiotics, for its optimal function. A low intake of these nutrients and bioactive compounds could increase a person’s risk of infections.

Because primary health care personnel and those who provide essential services to the community are at high risk of COVID-19 infection, they may need higher amounts of certain nutrients compared to the usual recommendations. Also, considering that these individuals need to wear personal protective equipment, work long shifts, sometimes under extreme conditions and have insufficient rest, high-stress levels, depression, poor nutrition and dehydration, an adequate diet is even more important.

Which nutrients are most essential in a daily diet for anyone who is on the front lines?

The key nutrients for strengthening the immune function are vitamins A, B3 (niacin), B9 (folate or folic acid), C, and D, and the minerals selenium and zinc. In addition, there are certain bioactive compounds that also are important for preventing infections, such as omega 3 fatty acids, polyphenols, probiotics, among others.

Should people be taking supplements (pills) to get these nutrients?

While many of the nutrients the body needs to stay healthy can be found in a balanced diet, it may be hard to get adequate amounts from diet alone – especially when the body needs an extra boost during times like these. We found that those on the front lines should be consuming individual supplements of three key nutrients: vitamin C, vitamin D and zinc.

The recommended amounts are:

  • 2000 mg of vitamin C per day, divided in smaller doses of 500-1000 mg throughout the day
  • 1000-2000 international units of vitamin D per day, divided into 2 doses and taken with food
  • 40 mg zinc per day

What other nutrients should those on the front lines be consuming?

We did not find sufficient evidence to suggest other dietary supplements that could help prevent respiratory infections. There are other nutrients and bioactive compounds that can support the immune function, and we recommended that those on the frontlines consume a variety of foods that are nutrient rich to help boost that immunity.

Some of the foods they recommend include: 

  • Dairy products, fish oil, eggs, liver, orange fruits and vegetables for vitamin A
  • Poultry, fish, nuts, and beans for vitamin B3 (niacin)
  • Green vegetables, beans, nuts and fruits for vitamin B9 (folate or folic acid)
  • Fish, shellfish, and nuts for selenium
  • fish, flaxseed, and chia for omega 3 fatty acids
  • Yogurt and fermented milk for probiotics
  • Green tea, blackberries, grapes, and cranberries for polyphenols

Are there other dietary recommendations that those on the front lines should be following?

It is recommended that those on the front lines follow the recommendation of consuming 400 grams per day of fruits and vegetables, which is equivalent to five servings. In addition, those wearing protective gear may need to consume more than six liters of water to remain hydrated. As a reference, one gallon of water is equal to 3.8 liters. Caffeine intake should not exceed 400 mg per day; as a reference, a cup of green or black tea has 30-50 mg and a cup of black coffee has about 100 mg.

5 habits to help boost immunity

5 habits to help boost immunity

  • May 21, 2020

When it comes to boosting our immunity, nothing beats healthy habits.

And while we can’t improve our immune systems overnight, Cleveland Clinic’s Kristin Kirkpatrick, a registered dietician, said we can start by looking at the foods we eat.

“If we look at specific foods, there have been studies on fiber,” she said. “Getting foods that have enough fiber have helped with immune function. Getting enough greens — greens in particular – seem to be like a magic elixir for helping that immune system stay in tip-top shape.”

Maintaining a healthy weight is another way to boost immune function.

Kirkpatrick advises us to take a look at not only what we’re eating, but also when we’re eating.

Need to drop a few pounds? One effective strategy is to eat all meals and snacks within an eight- to ten-hour window each day.

“When we are more in-line with our circadian clock — when we are eating during daylight hours, as humans should — that helps with overall fat loss, it helps with weight loss, it helps with immunity, it helps with so many concepts.”

Too much stress can have a negative impact on the immune system. And getting inadequate sleep hurts the body’s ability to fight off illness as well.

Kirkpatrick said many people think an alcoholic beverage can help them de-stress. However, she said having a few drinks will likely do more harm than good.

“Even though it’s a sedative, alcohol will wake you up in the middle of the night and it will make it harder for you to go back to sleep, so your sleep is really impacted,” said Kirkpatrick.

In addition to lost sleep, too much alcohol can have a negative impact on weight, the liver and a person’s overall health.

Kirkpatrick recommends enjoying alcohol minimally and keeping it to one drink per day or less.

Copyright 2020 by Cleveland Clinic News Service. All rights reserved.

Got Vitamin D? It May Mean Less Severe COVID-19

Got Vitamin D? It May Mean Less Severe COVID-19

  • May 21, 2020

There are many reasons to go outside for exercise while maintaining social distancing during the coronavirus pandemic. It’s good for the body and good for the mind.

Now there’s a new one: Vitamin D, which your body makes from the sunshine you’ll get outside, may mean milder COVID-19 illness. Diet and supplements are also sources of vitamin D. Vitamin D deficiency is widespread in the United States, especially in the elderly.

People who maintain adequate levels of vitamin D are more likely to have milder COVID-19 disease if they become infected with the new coronavirus, according to new studies presented in a Medscape video commentary by Harvard professor of medicine JoAnn E. Manson, PhD.

The vitamin plays a key role in immunity and is known to boost immune function against viral diseases, Manson notes. It also helps modulate immune response and can lower inflammation. That’s especially relevant when it comes to COVID-19, which can become particularly dangerous when it leads to the immune system overreaction known as a cytokine storm. Vitamin D modulates the response of white blood cells, preventing them from releasing too many inflammatory cytokines.

In one observational study from three South Asian hospitals, people with severe COVID-19 illness were much more likely to be vitamin D deficient. In another study, of 20 European countries, people with low vitamin D levels were likely to contract COVID-19 and more likely to die of it. A third study found that people with low levels were more likely to develop a cytokine storm and more likely to die of COVID-19.

Finally, a meta-analysis that pooled data from 25 randomized clinical trials looked at vitamin D supplementation. People given vitamin D supplements were 12% less likely to have severe respiratory symptoms. Among those with severe vitamin D deficiency, supplementation was associated with a 70% lower risk of severe respiratory infection.

“So the evidence is becoming quite compelling,” says Manson. “It’s important that we encourage our patients to be outdoors and physically active while maintaining social distancing. This will lead to increased synthesis of vitamin D in the skin, just from the incidental sun exposure.” (Note: The Skin Cancer Foundation recommends using sunscreen at all times when you are outside to reduce skin aging and help prevent skin cancer. People who wear sunscreen regularly still make plenty of vitamin D.)

Diet is another important source of vitamin D. Good food sources of vitamin D include fortified dairy products (such as milk), fortified cereals, fatty fish and sun-dried mushrooms. However, many people are not able to maintain healthy levels of vitamin D by going outside and eating vitamin D–rich foods, notes Manson. For them, it is “quite reasonable” to consider a vitamin D supplement.

While the recommended dietary allowance of vitamin D is 600 to 800 IU/daily (depending on age), “during this period, a multivitamin or supplement containing 1,000 to 2,000 IU/daily would be reasonable,” says Manson, who is chief of the Division of Preventive Medicine at Brigham and Women’s Hospital, in Boston. She is planning a randomized clinical trial to determine whether moderate to high doses of vitamin D may play a role in whether people become infected with the coronavirus in the first place, and, if so, how severe these infections become.

To watch the Medscape video, click here.

To learn more about sun protection, click here.

To get the latest updates on coronavirus, click here


Defective immune cells could make us old | Science

Defective immune cells could make us old | Science

  • May 21, 2020

Compared with a normal mouse (left), a mouse with defective mitochondria in its T cells appears old.

Elisa Carrasco

T cells are supposed to defend us from pathogens, but a new mouse study suggests they may also speed aging. Blocking inflammation caused by the cells or boosting their supply of a key metabolic molecule lessened the severity of some aging-related symptoms in rodents, raising the possibility these treatments could benefit older people.

The discovery is “a fantastic result directly linking metabolism, inflammation, and aging,” says immunologist Kylie Quinn of RMIT University, Bundoora, in Australia. “They’ve done a really thorough job of making sure it’s the T cells” that are causing the mice to age quickly.

Our T cells let us down as we age, becoming weaker pathogen fighters. This decline helps explain why elderly people are more susceptible to infections and less responsive to vaccines. One reason T cells falter as we get older is that mitochondria, the structures that serve as power plants inside cells, begin to malfunction.

But T cells might not just reflect aging. They could also promote it. Older people have chronic inflammation throughout the body, known as inflammaging, and researchers have proposed it spurs aging. T cells may stoke this process because they release inflammation-stimulating molecules.

To test that hypothesis, immunologist María Mittelbrunn of the University Hospital 12 October’s Health Research Institute and colleagues genetically modified mice to lack a protein in the mitochondria of their T cells. This alteration forces the cells to switch to a less efficient metabolic mechanism for obtaining energy.

By the time the rodents were 7 months old, typically the prime of life for a mouse, they already appeared to be in their dotage, the team reports today in Science. Compared with typical mice, the modified rodents were slow and sluggish. They had shrunken, weak muscles and were less resistant to infections. Like many elderly people, they suffered from weakened hearts and shed much of their body fat.

T cells from the altered mice poured out molecules that trigger inflammation, the team found, suggesting the cells could be partially responsible for the animals’ physical deterioration. “The immune system plays a role in increasing the velocity of aging,” Mittelbrunn says.

The scientists also tested whether they could slow the aging clock. First they dosed the mice with a drug that blocks tumour necrosis factor alpha (TNF-alpha), one of the inflammation-inducing molecules that T cells unleash; the treatment increased the animals’ grip strength, improved their performance in a maze, and boosted the heart’s pumping power.

Mittelbrunn and colleagues also gave the animals a compound that raises levels of nicotinamide adenine dinucleotide (NAD), a molecule that’s vital for metabolic reactions that enable cells to extract energy from food. NAD’s cellular concentrations typically decline with age, and the researchers found that ramping it up in the mice made them more active and strengthened their hearts.

Drugs that inhibit TNF-alpha are standard treatments for diseases such as rheumatoid arthritis and Crohn disease, and several companies now sell compounds that boost NAD levels. “It would be a good idea to go for clinical trials” to determine whether targeting TNF-alpha or NAD could reduce some of aging’s effects, Mittelbrunn says.

However, other researchers question the relevance of the results for normal aging. As mitochondrial biologist Navdeep Chandel of Northwestern University’s Feinberg School of Medicine notes, the mitochondria in the genetically modified mice are much more severely impaired than are the mitochondria of many older people. “For most of us, I bet our T cells are OK.”

However, he says, T cells with malfunctioning mitochondria may contribute to aging in some people who appear to get old prematurely and develop age-related diseases when they are relatively young. This mechanism may be a factor “in the unhealthy 70- or 80-year-old.”

Molecular cell biologist Judith Campisi of the Buck Institute for Research on Aging agrees. The study “adds a new layer of understanding” about how the immune system changes with age, she says. “To what extent it mimics natural aging, I don’t know.”

Plasma Therapy Boost Antibodies Level and Overall Immune System in Ailing Patients

Plasma Therapy Boost Antibodies Level and Overall Immune System in Ailing Patients

  • May 21, 2020

Plasma, an essential constituent of blood, carries proteins, vitamins, and hormones to other parts of the body. Also, it contains high amount of antibodies that help develop immunity system. Using plasma therapy, immunity of a healthy person is transferred using plasma to the one who required antibodies to fight against the medical condition.

Plasma therapy has been used since long for wound healing,androgenetic alopecia, and facial restoration. Some of the specific fields, it has been used significantly, are dermatology, dentistry, and orthopedics.

Advancement in medical science and growing application of plasma therapy in various life threatening diseases are contributing to expansion of the global plasma therapy market.

As per a report provided by the World Health Organization (WHO), approximately 18% women and 9.6% men above 60 years of age have symptomatic osteoarthritis. Among all, 80% have some sort of limitations in movement and 25% are not able to perform day-to-day activities.

Growing rate of orthopedic disorders is anticipated to drive the global plasma therapy market.

Growing Geriatric Patient Around Globe Pushing Demand for Plasma Therapy

Meanwhile, in recent years, geriatric population has increased exponentially. As per a report published by the World Health Organization (WHO), population aged 60 years and above is likely to rise from 605 million in 2000 to 2 billion in 2050. The geriatric population are susceptible to various kind of chronic and infectious diseases due to weak immune system. Hence, plasma therapy is extensively provided along with drugs to treat elderly population.

This, in turn, is anticipated to fuel demand for plasma therapy in coming years. Subsequently, plasma therapy is projected to rise exponentially.

Further, plasma therapy is also provided to sports person. According to report given by the National Center for Biotechnology Information (NCBI), in the U.S., approximately 86,000 athletes are treated with plasma therapy every years.

Growing rate of sports participation is also likely to push demand for plasma therapy in coming years. Hence, global plasma therapy makret is anticipated to expand at a significant rate.

Although plasma therapy is found to be quite effective, it is not effective in every medical condition. Also, high cost of plasma therapy is a barrier interfering with adoption rate of the therapy.
Aforementioned factors are restraining the global plasma therapy market.

Nevertheless, ongoing research and development activities is likely to provide new approaches for use of the therapy. New approaches may augment growth rate of the plasma therapy market.

Key companies operating in the global plasma therapy market are consistently trying to develop new application method of the plasma therapy. Key players are Biotest (Germany), BioLife Plasma Services (U.S.), Grifols International S.A. (Spain), Cambryn Biologics LLC (U.S.), CSL Ltd. (Australia), KedrionS.p.A. (Italy), LFB (France), Bio Products Laboratory Ltd. (U.K.), China Biologic Products, Inc. (China), and Octapharma (Switzerland).

Further, rising awareness regarding plasma therapy and its application as a suitable therapy for other tissues are propelling growth of the plasma therapy market.

To Get an Exhaustive Overview about the Competition in Plasma Therapy Market, Request for a Report Brochure at https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=77291

Outbreak of COVID-19 Channelized New Application of Plasma Therapy

Lately, demand for plasma therapy has increased suddenly due to unprecedented outbreak of novel coronavirus. The virus, primarily attacks immune system in human body and then target lungs. Initial symptoms of COVID-19 are fever and cold, which later transforms into pneumonia, bronchitis, breathlessness, and severe acute respiratory system (SARS). In case of weak immunity system,respiratory system fails. There are also instance of failure of more than one organs, resulting in death of the infected person.

As there is no specific treatment available for COVID-19, medical professionals are relying very much on strengthening the immune system. In cases where mediation seems to be ineffective, plasma therapy is being provided. As a result, demand for plasma therapy has been increases with rise in number of infection cases.

Also, since vaccine and antidote for novel coronavirus looks like a distant vision due to consistently changing feature of the virus, the global plasma therapy market is estimated to witness high demand rate in near future.

capsimmunesystem.org