ONCURIOUS I-O Portfolio Directed at Boosting T Cell Influx and Activity in Solid Tumors; Announcing First Preclinical Proof of Concept in Proprietary CCR8 Treg Program

ONCURIOUS I-O Portfolio Directed at Boosting T Cell Influx and Activity in Solid Tumors; Announcing First Preclinical Proof of Concept in Proprietary CCR8 Treg Program

  • October 22, 2020

– Strategic focus of immuno-oncology (I-O) portfolio on modulation of tumor microenvironment to enhance T cell influx and activity in immune excluded solid tumors, aspects that immune checkpoint inhibitors do not address.

– Preclinical Proof of Concept for Company’s priority I-O program, aiming at depleting regulatory T cells (Tregs) by targeting C-C motif chemokine receptor 8 (CCR8) 

Initiating lead optimization phase in proprietary CCR8 Treg Program.

Preclinical development of therapeutic antibody program expected to start in early 2021.

LEUVEN, Belgium, Oct. 22, 2020 /PRNewswire/ — ONCURIOUS NV, a Belgium-based biotech company focused on developing innovative immune-oncology treatments, today presents its strategy directed at boosting T cell migration, infiltration and activity into solid tumors, and announces that it has reached preclinical proof of concept and has entered the lead optimization phase with its proprietary CCR8 Treg program.

This important milestone follows Oncurious’ decision to focus its development activities on a pipeline of promising novel immune-oncology targets and drug discovery projects.

Oncurious scientists, in collaboration with world-class immuno-oncology experts in T cell and endothelial cell biology – Prof. Dr. Gabriele Bergers (VIB-KU Leuven), Prof. Dr. Massimiliano Mazzone (VIB-KU Leuven) and Prof. Dr. Jo Van Ginderachter (VIB-VUB), and the drug discovery unit at VIB, are building a pipeline of proprietary investigational I-O therapies with distinct mode of actions.

The team has discovered a potent and diverse panel of leads targeting human CCR8, has reached preclinical proof of concept and is entering the final lead optimization stages nearing preclinical candidate selection. Oncurious is now accelerating its efforts towards initiation of preclinical development of the therapeutic antibody program in early 2021.

CCR8 has been validated to be a tumor-infiltrating Treg-specific marker in solid tumors in both patients and animal models, making it the preferred target for therapeutic depletion of Tregs in cancer.

Oncurious’ CCR8 leads have been generated using an antibody technology platform that has been validated and used for more than a decade to generate high quality binders against G-protein coupled receptors. Molecules discovered using this technology were tested in several preclinical tumor models, and showed that targeting CCR8, depleted Tregs specifically in the tumor microenvironment and resulted in strong anti-tumor responses in monotherapy as well as in combination with anti-PD1. The treatments led to the establishment of immunological memory.

Next to the anti-CCR8 program, Oncurious is focusing on 2 other programs aimed at boosting anti-tumor T cell influx and activity in immune excluded tumors. Exclusion of T cells is an immunosuppressive mechanism commonly used by cancers to evade the immune system and as such is an attractive target for new therapeutic modalities.

The company expects to make further announcements regarding its progress in the near future.

Patrik De Haes, M.D., Executive Chairman of ONCURIOUS NV comments, “I am excited about the future of Oncurious based on its portfolio of novel, differentiated I-O therapies. The company’s approach is to generate novel drug candidates to treat immune excluded solid tumors that are not adequately addressed by immune checkpoint inhibitors, which are rapidly becoming the mainstay of cancer therapy. Today we are announcing significant progress in both hit and lead generation against novel I-O targets, including CCR8, which we believe could play a key role in the development of innovative immunotherapies to overcome solid tumor resistance. Working with leading scientists in the field, we aim to be at the forefront of a new wave of the I-O revolution and are confident that by delivering on our goals we can build Oncurious into a company of significant value in the years ahead. We look forward to updating you on our further progress.”

Jérôme Van Biervliet, Managing Director at VIB comments: “We are very pleased to see Oncurious’ anti-CCR8 antibody reach this important step towards preclinical development, not least thanks to the model collaboration with VIB Discovery Sciences.  Side-by-side with the Oncurious team, they are accelerating a promising pipeline of investigational immuno-oncology therapies.”

For further information please contact:

Oncurious NV

Wouter Piepers,

Investor Relations

& Corporate Communications

Tel: +32 478 33 56 32

[email protected] 

VIB

Elisabeth Stes

External Relations Manager

+32 9 244 66 11 / +32 486 82 59 02

[email protected] 

Citigate Dewe Rogerson

David Dible/ Sylvie Berrebi/Frazer Hall

Tel: +44 20 7638 9571

[email protected]

 

About ONCURIOUS

Oncurious is a Belgium-based biotech company focused on developing innovative oncology treatments derived from a series of promising new targets that are designed to enhance T cell activity, migration and influx into resistant tumour sites, boosting the patient’s own immune response against cancer. The company’s lead immune-oncology asset is a Treg-depleting asset, targeting a protein specifically expressed on Tregs in the tumour microenvironment. The program is in lead optimization. The company’s two other programs are focused on T cell migration and are in the discovery stages. 

Immuno-oncology made a major step forward in the treatment of cancer with the advent of immune checkpoint inhibitors, which are expected to represent a market opportunity of $50bn by 2025 (GlobalData 2020). Despite this clinical and commercial success, there remains an important need to develop new I-O approaches that improve efficacy, overcome resistance, and that can synergize with checkpoint inhibitors so that more patients with solid tumors can benefit from these life-saving therapies.

Oncurious’ early stage pipeline of novel immune-oncology programs offer the potential to overcome tumor resistance mechanisms, that current immune checkpoint inhibitors cannot address, and thereby significantly enhance the responses to immunotherapy across multiple tumor types.

More information: www.oncurious.com

About VIB

VIB is an excellence-based entrepreneurial research institute in life sciences located in Flanders, Belgium. VIB’s basic research leads to new and innovative insights into normal and pathological life processes. It unites the expertise of all its collaborators and research groups in a single institute, firmly based on its close partnership with 5 Flemish universities (Ghent University, KU Leuven, University of Antwerp, Vrije Universiteit Brussel and Hasselt University) and supported by a solid funding program from the Flemish government.

VIB has an excellent track record on translating basic scientific results into pharmaceutical, agricultural and industrial applications. Since its foundation in 1996, VIB has created 25 start-up companies, now employing over 900 people. The link between basic research and valorisation has made VIB a catalyst for the ever-growing biotech hotspot in Flanders. In recent years, numerous biotech companies — both large and small — have settled down in the region, thanks to top-notch infrastructure set up and provided by VIB and the ready availability of new scientific talent from the VIB labs.

More information: www.vib.be

SOURCE Oncurious NV

Pandemic-Era Shoppers Splurge on Vitamins, Boosting Nestlé Sales

Pandemic-Era Shoppers Splurge on Vitamins, Boosting Nestlé Sales

  • October 21, 2020

Nestlé SA


NSRGY 0.35%

said the pandemic has increased consumers’ health consciousness, boosting its small but fast-growing health-sciences unit and contributing to better-than-expected overall sales at the world’s largest packaged-food maker.

The owner of Nescafe coffee, DiGiorno frozen pizza and Purina pet food has previously benefited from a pandemic-era shift by consumers to comfort food—particularly big, trusted brands—as they stocked up and stayed home during lockdowns.

As the pandemic wears on, companies are now getting a boost as consumers gravitate toward products that boost health, particularly the immune system.

Nestlé’s health-science business has been one of its lesser-known divisions for years, but Chief Executive Mark Schneider, a former health-care executive who took the reins in 2017, has turned it into a focus area amid a wide-ranging portfolio shake-up. The unit represents only about 3% of Nestlé’s overall sales, but Mr. Schneider said Wednesday he wanted it to become “a health and nutrition powerhouse” through acquisitions and organic growth.

Nestlé said the unit delivered double-digit sales growth in the first nine months of the year, but didn’t detail its performance any further in a sales update released Wednesday.

Demand for vitamins, minerals and supplements was strong, the company said. Supplement brands Garden of Life and Pure Encapsulations sold particularly well online. So called healthy-aging products grew at a double-digit rate in the nine-month period, Nestlé said, with help from Boost, a nutritional drink brand, in North America and Nutren, a line of nutritional supplements, in Brazil.

Health-science sales lifted overall revenue, which was powered by strong pet food and coffee sales. Nestlé said organic sales, which strip out currency fluctuations, acquisitions and divestitures, grew 3.5% in the first nine months of the year, beating analysts’ estimates of 2.8%. Results were driven almost entirely by volume growth. The company upgraded its guidance for the year, saying it now expects organic sales growth of around 3%, from a prior forecast of between 2% and 3%.

Nestlé shares were largely unchanged in late morning trading in Europe.

Net sales fell 9.4%, to 61.91 billion Swiss francs, equivalent to $68.24 billion, dragged down by currency changes and divestitures. Mr. Schneider has sold a string of assets, including Nestlé’s skin-health arm and U.S. ice-cream business, as he pivots toward categories he sees as higher growth.

Other companies have reported sales boosts amid a shift in health consciousness by consumers.

Conagra Brands Inc.

says its Healthy Choice frozen meals are on the rise.

Reckitt Benckiser Group

PLC this week said its Airborne brand, a supplement advertised as boosting the immune system, more than doubled revenue in the third quarter.

Others have moved to take advantage of the increased concern about health during the pandemic.

Unilever

PLC has doubled the amount of zinc that goes in its Horlicks brand, a malted milk bestseller in India, and is marketing what it says are the brand’s immunity-boosting benefits.

Nestlé has a head start, having set up the health-science business in 2011 under former CEO Paul Bulcke, now the company’s chairman. His vision was to use specialist food-based products to help prevent and treat conditions such as Alzheimer’s disease, diabetes and heart disease. Nestle has also been investing in treatments and medicine.

It has made a long string of acquisitions to bolster the unit, earlier this month closing a deal to buy a California-based biopharmaceutical company that has won approval for the first treatment for peanut allergies. The acquisition valued Aimmune Therapeutics Inc. at $2.6 billion, including debt, and analysts expect Nestle to keep doing big deals.

This year, Nestlé bought a gastrointestinal medication brand and took a majority stake in a company that makes collagen supplements.

Still, for all the focus on it, the health-science arm remains far smaller than older units such as coffee and petcare, which remained the main drivers of Nestlé’s strong sales for the period. Pet food, where sales rose 4.1% in the nine months, has performed well for years.

The company said its dairy and cooking-aids arms also did well. Confectionery and bottled water dragged down the results, with both categories heavily dependent on tourism and shoppers being out and about.

After lifting lockdowns, many countries—particularly in Europe—are now implementing strict bans on movement again to stem the spread of the virus. Nestle said the out-of-home sales channel overall “remained significantly negative,” but sales declines moderated in the third quarter.

Write to Saabira Chaudhuri at saabira.chaudhuri@wsj.com

Copyright ©2020 Dow Jones & Company, Inc. All Rights Reserved. 87990cbe856818d5eddac44c7b1cdeb8

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Why you can’t escape the flu and COVID-19 just by ‘boosting’ your immunity

  • October 20, 2020

Article content continued

“Even the effectiveness of multivitamins is disputable because they contain a lot of things you don’t actually need,” Lager says. “If you need to supplement something because you aren’t getting it in your diet, then take the actual supplement you need rather than a multivitamin.”

Taking excessive amounts of vitamins and minerals can also be pointless and sometimes harmful.

We apologize, but this video has failed to load.

“Vitamin C deficiency in North America is extremely rare and because it’s water soluble, taking excessive amounts of it just means it will be excreted in your urine,” Cross says. “While Zinc has shown to have some beneficial properties, taking too much of it will cause deficiencies in other trace minerals, so you should really only be doing that based on a doctor’s recommendation.”

The one exception to the rule is vitamin D, where deficiencies in this protein are linked to an increased risk of infection. The problem is, not many foods are rich in vitamin D, which means taking this supplement is recommended — at the appropriate dose, of course.

Cross also says she takes an omega-3 supplement because she doesn’t get enough of it in her daily diet.

“Remember that if there was one supplement that truly optimized your immune system, then it wouldn’t be available only via multi-level marketing or in health food stores — it would be properly regulated,” Langer says.

At the end of the day, living a healthy lifestyle — a balanced diet, exercise and lots of sleep — is what will give you the best chance of keeping the flu and other illnesses at bay.

HealthXP Launches Shield Whey – An Immunity Boosting Whey Protein

HealthXP Launches Shield Whey – An Immunity Boosting Whey Protein

  • October 14, 2020

The COVID-19 pandemic has been a wake-up call that highlighted the importance of having a strong immune system and being fit to the whole world. Today, staying fit and building not only their own, but also the immunity of their entire family, by consuming the right micro and macro nutrients, is on everybody’s priority list. The entrepreneur duo, Girish Joshi and Sarvesh Moghe, have been dedicated to promoting wellness and building a fit society since 2014, when they launched Xpresshop Online Store to source and sell health supplements over the internet.

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After three years they rebranded and launched their own health nutrition platform called HealthXP.in, where fitness enthusiasts could purchase a wide range of affordable and reliable dietary supplements from the website as well as receive guidance on fitness, workouts and nutrition; in short, a one-stop-shop for everything to do with fitness. Within its first year of operations itself, HealthXP became one of the most trusted websites where one could buy authentic and genuine health supplements. With their holistic approach to fitness, HealthXP won ‘Best Health Startup of 2018’ at the Indian Health and Wellness Summit Awards.

The young and driven partners of HealthXP Online Store, Mr Girish Joshi & Mr. Sarvesh Moghe were felicitated recently as “Young Entrepreneurs in Online Health Platforms” at the ET Industry Leaders – West 2020, an initiative that honoured and celebrated visionary business enterprises and individuals who continued to prove their mettle, exude confidence through innovation and retained their market position; despite the pandemic. You can shop for your favourite vitamins, supplements, and sports nutrition products to support all your health and fitness goals on the HealthXP app, one of the largest online supplement stores in India.

In 2019, they have pumped in their years of experience understanding the fitness and nutritional needs of various individuals to create their own line of high-end supplements under the same brand name. This line provides you with a wide range of products including whey proteins, mass gainers and even recovery supplements like BCAAs. They received an overwhelming response for all their products, not only on the HealthXP portal but on other portals as well. Today HealthXP is ranked amongst the top 3 Indian brands of Health Supplements, their biggest USP being variety in the range of products with a choice of amazing flavours, which are not available in any other indigenous brand; ranking HealthXP far ahead of its peers.

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Recognising the need of the hour, HealthXP recently launched an innovative product called Shield Whey, which combines whey protein with an array of immunity boosters. This path-breaking product ensures that a single product will take care of their nutrition as well as immunity needs of the individual, eliminating the need to consume multiple products.

Like all HealthXP products, the newly launched Shield Whey strives to deliver a healthy dose of multivitamins and immunity boosters along with other high quality ingredients. If you still need convincing, read on to know about the ingredients and the additional benefits they provide.

  • Vitamin C, Vitamin K & Vitamin E helps boost immunity, improves muscle and overall performance
  • Ashwagandha (Withania Somnifera) builds muscle mass & improves muscular strength. It also helps overcome fatigue
  • Calcium & Vitamin D help in maintaining bone & joint strength. They also maintain health of the overall bone & joint
  • Milk Thistle promotes healthy and robust liver function and enhances overall body performance
  • It has zero added sugar

Today HealthXP is one of the fastest growing online nutritional supplement stores. In the near future, HealthXP plans to collaborate with top fitness brands of India. They are also looking at enhancing their presence through expansion of warehouses and offline stores across India. Along with making HealthXP one of the biggest fitness marketplaces in India, their aim is also to simultaneously reduce the presence of counterfeit health supplements and harmful drugs in the market.

The amazing immunity boosting Shield Whey is just a click away. Click on https://healthxp.in/product/healthxp-shield-whey-1kg?utm_source=toi&utm_medium=healthxp-shield to buy Shield Whey now.

Disclaimer: This article has been produced on behalf of HealthXP by Mediawire team.

Nutrient Survival Launches Immune Boosting and Therapy Products To Support Immune System Defense

Nutrient Survival Launches Immune Boosting and Therapy Products To Support Immune System Defense

  • October 13, 2020

RENO, Nevada– Nutrient Survival, an end-to-end start-up emergency food and beverage technology company, is thrilled to announce the launch of its Revive Therapy and Immune Boost beverage mix packets.  No matter the season, Nutrient Survival is here to help you get the essential nutrients your body needs.

“The threat of viruses has never been greater for us, even as we learn to make changes to our everyday lives to keep ourselves and others safe,” said Nutrient Survival CEO Eric Christianson.  “We just had to do more to help people defend their bodies by bringing together our proprietary blend of essential nutrients and other powerful ingredients in these new drinks to support boosting immunity and help with symptom recovery.”

For proactive everyday use, the Immune Boost formula is optimized to help your body’s defenses support your immune system through a powerful blend of Vitamins A,C and E for cell protection, Vitamin B complex for sustained energy, ginger & green tea for immune support, magnesium for muscle strength, quercetin to reduce inflammation, and zinc to help with immune system defense.

For when symptoms start to show, the Revive Therapy formula is made to aid fast recovery through a powerful blend of zinc for sore throat soothing, cranberries to support your immune system, myrrh to help relieve pain, Vitamins A,C and E for a powerful antioxidant boost, and BCP (Beta-Caryophyllene) to help reduce inflammation.

Boasting only 0-10 calories, both innovations have effective and potent ingredients that are gluten free, GMO free, and have no preservatives or artificial sweeteners. To use, just mix the packets in 6-8 oz. of water, shake well and enjoy.

New Nutrient Survival Immune Boost are $42 for 30 single-serve sticks and Revive Therapy are $30 for 10 single-serve sticks, now available for purchase on NutrientSurvival.com. Keep up to date with the latest news by following along on Instagram and Facebook.

* These are not intended to treat, cure, or prevent any disease. If you’re not feeling well, please check with your primary care provider.

Nutrient Survival Launches First of its Kind Immune Boosting and Therapy Products To Support Immune System Defense

Nutrient Survival Launches First of its Kind Immune Boosting and Therapy Products To Support Immune System Defense

  • October 13, 2020

“The threat of viruses has never been greater for us, even as we learn to make changes to our everyday lives to keep ourselves and others safe,” said Nutrient Survival CEO Eric Christianson. “We just had to do more to help people defend their bodies by bringing together our proprietary blend of essential nutrients and other powerful ingredients in these new drinks to support boosting immunity and help with symptom recovery.”

For proactive everyday use, the Immune Boost formula is optimized to help your body’s defenses support your immune system through a powerful blend of Vitamins A,C and E for cell protection, Vitamin B complex for sustained energy, ginger & green tea for immune support, magnesium for muscle strength, quercetin to reduce inflammation, and zinc to help with immune system defense.

For when symptoms start to show, the Revive Therapy formula is made to aid fast recovery through a powerful blend of zinc for sore throat soothing, cranberries to support your immune system, myrrh to help relieve pain, Vitamins A,C and E for a powerful antioxidant boost, and BCP (Beta-Caryophyllene) to help reduce inflammation. 

Boasting only 0-10 calories, both innovations have effective and potent ingredients that are gluten free, GMO free, and have no preservatives or artificial sweeteners. To use, just mix the packets in 6-8 oz. of water, shake well and enjoy.

New Nutrient Survival Immune Boost are $42 for 30 single-serve sticks and Revive Therapy are $30 for 10 single-serve sticks, now available for purchase on NutrientSurvival.com. Keep up to date with the latest news by following along on Instagram and Facebook

* These are not intended to treat, cure, or prevent any disease. If you’re not feeling well, please check with your primary care provider.

Media Contact: Mia Fazio
[email protected]

SOURCE Nutrient Survival

Related Links

https://nutrientsurvival.com/

Rich in antioxidants, pomegranate is one of the healthiest fruits to include in your diet.

From releasing stress to boosting memory, here are 6 benefits of pomegranate – health

  • October 13, 2020

If the bright colour and unique shape of pomegranates is not enough to lure you, then we think its health benefits will surely win you over! Rich in antioxidants, vitamins A, C and E, pomegranate is a nutrient-dense fruit that you consume regularly without a doubt!

Consuming this fruit regularly can really boost your health. Excited to find out? Let’s tell you all about it!

1. STRENGTHENS YOUR BONES

If you are looking for something that can naturally boost your bone health, then look no further than the pomegranate. The fruit helps to prevent loss of bone density, because of its high content of flavonoids. These flavonoids fight any inflammation in the body, which otherwise leads to problems like cartilage damage and osteoarthritis.

Moreover, a study published in the Journal of Nutrition suggests that pomegranate extract can block enzymes which are responsible for the damage in joints amongst people with osteoarthritis.

2. RELEASES STRESS

Pomegranate is known to reduce oxidative stress from the body, but apart from that, it can also help lower psychological stress. A study conducted by the Queen Margaret University found that people who consumed pomegranate juice regularly had lower levels of cortisol hormones in their body. So, now you might want to munch on some pomegranate, post a stressful day?

3. BOOSTS IMMUNITY

Pomegranate is rich in antioxidants and vitamin C, which make it a great immune-boosting food. The vitamin C helps to boost antibodies, which in turn, helps your body to fight the disease-causing germs.

4. AIDS IN DIGESTION

Pomegranate is a great source of fibre, and we all know the importance of fibre for a healthy digestive system. Adding pomegranate to your diet is the easiest and tastiest way of enhancing health!

5. IMPROVES MEMORY

In a study published in the journal Evidence-Based Complementary and Alternative Medicine, it was found that only about two grams of pomegranate extract can prevent deficit in memory. In another study, they also found that consuming about 250 ml of pomegranate juice can improve visual and verbal memory power.

6. KEEPS THE HEART HEALTHY

Pomegranate has proven to lower blood pressure. A study published in the journal Phytotherapy Research made the participants consume about 150 ml of pomegranate juice daily for a span of two weeks. After two weeks, they recorded a significant reduction in their blood pressure. And as you know hypertension is one of the leading causes of heart strokes. So, consume pomegranate regularly to boost your heart health.

But if you are a heart patient do not make any changes without consulting your doctor first.

All set to nosh on pomegranate? Do we hear a BIG yes?

(This story was originally published on HealthShots.com)

‘Immune boosting’ tuberculosis vaccine could help in Covid-19 fight | UK | News

‘Immune boosting’ tuberculosis vaccine could help in Covid-19 fight | UK | News

  • October 11, 2020

The Bacillus Calmette-Guerin (BCG) vaccine will be trialled globally to 10,000 people after the injection was found to stimulate the immune system. It could help people fight off COVID-19 until more effective vaccines are discovered. The trial will see participants either given the BCG vaccine, which is currently given to more than 100 million babies worldwide each year, or a placebo injection.

The study has received more than 10 million US dollars (£7.6million) from the Bill and Melinda Gates Foundation to allow it to expand globally.

The University of Exeter is leading the UK arm of the trial and will soon recruit healthcare staff and care home workers in the UK.

Researchers are targetting professionals who work in jobs which have a high exposure to COVID-19.

The study is being coordinated by the Murdoch Children’s Research Institute in Melbourne Australia.

The UK will join forces with study centres in Australia, the Netherlands, Spain and Brazil in what will be the largest trial of its kind.

In the UK, routine BCG vaccination was stopped in 2005 because of low rates of TB in the general population.

Professor John Campbell, of the University of Exeter Medical School, said: “COIVD-19 has killed more than a million people globally, with well over 33 million people acquiring the disease, sometimes in its severest forms.

“BCG has been shown to boost immunity in a generalised way, which may offer some protection against COVID-19.

“We’re excited to be contributing to the large-scale, international study where we are seeking to establish whether the BCG vaccine could help protect people who are at risk of COVID-19.

“If it does, we could save lives by administering or topping up this readily available and cost-effective vaccination.”

Researchers are looking to see if the BCG vaccine, which works by boosting immunity by “training” the body to respond to other subsequent infections with greater intensity.

It is hoped this improved “innate immunity” will buy crucial time needed to develop an effective and safe vaccine against COVID-19.

Prof Campbell added: “People on the COVID-19 front line, including healthcare workers and care home workers, are particularly vulnerable to coronavirus infection.

“Up until now, care home workers have been overlooked by most research.

“The trial provides us with a great opportunity to offer potential help to this important group of individuals who are providing healthcare to some of our most vulnerable citizens in important community settings.

“I’d really encourage care home staff to join us, to help us find out if the BCG vaccine might provide a safe, widely available and cost-effective way to reduce the risk of COVID-19.”

MAPI Broiler-at-pan.jpg

Boosting chickens own immune response could curb disease

  • October 8, 2020

Broiler chicken producers the world over are all too familiar with coccidiosis, a parasite-borne intestinal disease that stalls growth and winnows flocks.

According to the University of Illinois, various approaches — developed over decades — have been used to control coccidiosis, but the disease remains widespread. Now, recent research from the University of Illinois supports the use of immunomodulatory and antioxidant feed additives to reduce the effects of coccidiosis.

“In the last two decades, partially to get around the parasite’s resistance to pharmaceuticals, vaccination has become more prevalent. That’s when I got interested, because nutrition is a key element in the effectiveness of vaccines. Diet and health go together in that way,” said Ryan Dilger, associate professor in the department of animal sciences at the University of Illinois and principal investigator on the research. “So, what we’re talking about here is not a vaccine. Instead, we used nutritional technologies to disrupt the normal reproductive cycle of the parasite.”

When a chicken picks up the parasite, of which there are seven major Eimeria species affecting broilers, its body mounts an immune response, starting with a cascade of inflammatory proteins known as cytokines. These cause the bird to stop eating and rest, so the immune system can do its work. In normal disease progression, an anti-inflammatory mediator known as interleukin-10 (IL-10) is eventually produced to keep the inflammation from ramping up too high and causing tissue damage through oxidative stress, Dilger explained.

However, eimeria tricks chickens into over-producing IL-10 earlier than expected, before the immune system can produce enough cytokines to effectively attack the invader. “It’s like the parasite is saying, ‘Everything’s fine. I’m not actually here!’ It’s really trying to evade the immune response,” Dilger said.

To reverse that effect, doctoral student Muhammed Shameer Abdul Rasheed included a novel feed ingredient, a dried egg product with IL-10 antibody activity, in the diet of broiler chickens before inducing coccidiosis.

“We want the bird to have an acute pro-inflammatory response in order to clear the parasite, and that response is dampened when the parasite tricks the bird into overproducing IL-10 antibody. We’re trying to take away the parasite’s ability to manipulate the bird’s own immune system against itself,” Rasheed said.

The IL-10 dried egg product has been shown to be effective against mild eimeria infection in other studies, but it hadn’t been tested in severe cases and in the absence of vaccine administration.

“Our results suggested that dietary dried egg product could be beneficial in promoting gut health during severe infection for particular strains of the parasite, even though suppression of the IL-10 response may promote an exaggerated inflammatory reaction in the intestinal epithelium, which may cause subsequent tissue damage,” Dilger added.

Uncontrolled inflammatory responses can lead to oxidative stress, where chemicals with unpaired electrons, known as free radicals, start to damage healthy tissue. When Rasheed saw the intestinal damage in this study, he decided to test the combined effects of the IL-10 antibody and an antioxidant known as methylsulfonylmethane (MSM). He had previously tested MSM in chickens and found it had no adverse effects on health or growth, but it had never been tried as a treatment for oxidative stress during coccidiosis.

“The IL-10 antibody works to combat the infection through an immune mechanism, which may inadvertently cause oxidative stress, so MSM was used in combination to specifically combat that tissue damage,” Rasheed said. “So, the hypothesis was that if these two interventions are working through different mechanisms, combining them together may actually give us a better response than either of them alone.”

When the research team fed infected birds a combination of MSM and IL-10 antibody, the treatment showed promise. First, chickens that got the treatment showed greater bodyweight gain 7-14 days post-infection than birds that didn’t consume the dietary products. Also, total antioxidant capacity, an overall indicator of how well an animal can counteract oxidative stress, remained higher in treated birds three and four weeks after infection, suggesting lasting dietary effects, the researchers said.

“In the end, the birds still got sick; they still had an infection that reduced their growth for a certain amount of time. Just like with some pharmaceutical agents designed to lessen the effects of the flu in humans, it’s not actually going to prevent you from getting the disease in the first place. However, our goal is to shorten the length of time you’re sick,” Dilger said. “That’s just as meaningful for broiler chickens.”

Dilger said he thinks the dietary interventions may be even more effective in real-world production settings. In the clean, controlled environment of a laboratory study, these broiler chickens were raised on wire flooring to separate the birds from their excrement. However, broiler chickens raised on a commercial farm would be raised on the floor, in direct contact with litter, which is partly how the eimeria infection cycle continues. In the end, the nutritional strategies studied here may act as a kind of insurance for producers to help birds bounce back sooner.

“Producers may not have coccidiosis when they mix this in the feed, but by the time the chickens consume it, the disease may have reared up again. So, if the product is already there, you have some protection,” Dilger said. “Again, it’s not going to prevent the birds from getting coccidiosis, but hopefully it can reduce the untoward effects and allow them to get back to a healthy state faster and continue growing, such that they can remain productive during that time. It’s another important tool in the arsenal for producers.”

The articles, “Dietary supplementation with anti-IL-10 antibody during a severe Eimeria challenge in broiler chickens” and “Effects of methylsulfonylmethane and neutralizing anti- IL-10 antibody supplementation during a mild Eimeria challenge infection in broiler chickens” were published in Poultry Science. M.S. Abdul Rasheed is first author on both articles, and Elanco Animal Health sponsored both studies.

Plix drives the message of ‘boosting immunity- a must’ in new campaign, Marketing & Advertising News, ET BrandEquity

Plix drives the message of ‘boosting immunity- a must’ in new campaign, Marketing & Advertising News, ET BrandEquity

  • October 8, 2020
Plix drives the message of ‘boosting immunity- a must’ in new campaign
Plix drives the message of ‘boosting immunity- a must’ in new campaign

Plant based nourisher, Plix has launched a campaign ‘My Unlock Story’ to create an awareness about the importance of building strong Immunity and holistic living

Conceptualised by Gozoop, the campaign features Ranvijay Singha leading the cause by posting a video on Instagram talking about how it is important to take care of our health and build a strong immunity especially now that we enter the unlock phase and help the nation get through the pandemic together.

Singha also urged everyone to share their inspiring stories on how they are fighting the pandemic and encourage other people.

To create further awareness 150 influencers from various dimensions of life such as fitness experts, nutritionists, celebrities came on board with Plix and urged everyone to adopt a healthy lifestyle and focus on strengthening their immune system.

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Rishubh Satiya, founder and chief executive officer, Plix, said, “With the help of collective participation and support to this movement we aim to educate people about the importance of Immunity and holistic living. At Plix we always believe that everyone should be taking care of their nutritional needs, hence our product range caters to every individual who is striving hard to stay strong during this pandemic.”

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