Dentitox Pro – Improve Your Teeth with a Daily Gum Health Serum

Dentitox Pro – Improve Your Teeth with a Daily Gum Health Serum

  • June 17, 2021

Dentitox Pro is a daily oral care product that uses nutrients from plants that help consumers improve their teeth and gums without replacing the user’s current routine. The formula is easy to apply each day, though consumers will need to keep up with using this remedy consistently to make a difference.

What is Dentitox Pro?

Dental health is just as important as physical fitness and the right nutrition for the body. The way someone takes care of their teeth can make a difference in their health since every nutrient they consume goes through their mouth first. The mouth is also filled with different types of bacteria, and these microorganisms can build up and cause cavities if not cared for properly. The use of Dentitox Pro can be a helpful solution for individuals that want to improve their dental health.

There is extraordinarily little information available with Dentitox Pro. Still, it was developed by Marc Hall, who has a passion for the changes that plants can have in consumers’ health everywhere. The remedy consists of many common ingredients that users find in toothpaste and mouthwash, but several other plants make a big difference.

How Dentitox Pro Works

The Dentitox Pro formula focuses on delivering nutrients that the body needs. Within just 6 drops of the formula, consumers will get a ton of different nutrients that their body already needs to maintain for better health, like vitamins A, C, D3, and K2. It even includes many minerals like potassium and calcium.

However, with all of these typical ingredients, consumers would seemingly get the same support from simply using a multivitamin. That’s why there are additional ingredients that make the performance of this remedy even more intense, including:

  • Elderberry
  • Ironized phosphoric acid
  • Xylitol
  • Collagen
  • MSM
  • Indian licorice root extract
  • Neem
  • Sage
  • Cinnamon essential oil
  • Peppermint essential oil

Whenever the user decides to include the Dentitox Pro drops in their routine, they should apply them directly to the teeth and gums. Brushing the teeth is still necessary to maintain oral health, but Dentitox Pro provides a way to boost that health.

Read on below to learn about each of these ingredients’ role in dental and oral health.



Elderberry covers several different types of trees, covered in white flowers and deep-blue berries. It is often used to deliver important antioxidants to the user, though some suggest that it can improve the immune system. The berries cannot be eaten in their natural state, so they are typically used as a supplement.

As helpful as elderberry might be, some consumers can have an adverse reaction to it if they consume more than they intended. Some of the signs that users may have taken in too much include nausea, weakness, dizziness, and stupor.

Ironized Phosphoric Acid

Phosphoric acid comes from phosphorus, which the body uses with calcium to keep the teeth and bones strong. It keeps kidney function under control, and it helps the body store energy safely.


Xylitol is primarily used as a low-calorie substitute for sugar, providing users with an option that is low in sugar. Most of the time, this ingredient is used in gums and similar products to keep the teeth and gums healthy. Studies show that xylitol can reduce the harmful bacteria in the mouth by starving it of the nutrients that it would need to survive. It also can reduce plaque and ultimately prevent tooth decay, which means that users have a greater form of protection against inflammatory gum disease.

This ingredient is also helpful in preventing ear infections, and it supports the body’s need for antioxidants. It is also a type of sugar alcohol, though it doesn’t actually contain any alcohol whatsoever. Sugar alcohols are simply a type of carbohydrate.


Most people think of collagen as a skincare ingredient because it reduces wrinkles and improves skin health. It is also directly associated with relief from joint pain, though it may be used in this oral health supplement to prevent bone loss. As time goes on, bone density improves, even if it has weakened with age.

Using a supplement is the easiest way to improve collagen levels, helping the body improve hydration.


MSM is typically included to reduce pain in the joints, complementing the use of collagen perfectly. It can reduce inflammation, which commonly occurs in irritated gums when they become infected. MSM is sometimes connected with relief from allergy symptoms, and it can improve the body’s ability to recover after an intense workout.

The research behind MSM shows that this nutrient also has a powerful effect on the immune system, which means that users will heal faster when they need dental care.

Indian Licorice Root Extract

Indian Licorice Root Extract offers tons of antioxidants to reduce inflammation and provides the user with antimicrobial benefits. When used regularly, there’s a chance that this extract can reduce the risk of infections in the upper respiratory tract, and it can improve the way that the body digests different nutrients.

Digestion has a major role in the health of the mouth. The bacteria and acid in the stomach can easily become imbalanced, causing issues in the esophagus. These bacteria can then infiltrate the gums and mouth, causing damage to the teeth. However, balancing the needs of the digestive system can make a huge difference.


Neem is a leaf, and it is used for the treatment of many ailments for the body. A few of the problems that it can help to deal with include appetite loss, skin ulcers, intestinal worms, upset stomach, and even diabetes. However, the biggest reason this ingredient is probably included in the formula has to do with the nourishment it provides individuals who experience gingivitis.

Gingivitis is a type of gum disease, and it often causes redness, inflammation, and irritation around the bottoms of the teeth. While it can be reversed, consumers need to improve their oral hygiene to protect them from recurrence.


Sage has tons of nutrients that the body can benefit from. Sage is incredibly beneficial for oral health because it can reduce the microbes responsible for dental plaque. Typically, it can be used topically in mouthwashes to kill off the bacteria primarily known for leading to dental cavities.

The anti-inflammatory benefits are helpful to individuals who are struggling with swollen gums or infections.

Essential Oils

Dentitox Pro includes both cinnamon and peppermint essential oils. While cinnamon essential oil is associated with reduced bacteria and fungal growths in the month, peppermint is typically used for joint pain or headaches. Both of these essential oils are rather strong, but they are diluted for the right benefit and taste of the formula.

Both oils can be used to alleviate stress and improve relaxation.

Purchasing Dentitox Pro

While there are many oral hygiene products on the market today, nothing is quite like the Dentitox Pro formula. Consumers will only be able to purchase this formula from the official website; there are a few packages they can choose from:

Those packages include:

Even if the user doesn’t find that they get the healing they hoped for with Dentitox Pro, they have up to 60 days to speak with customer service about getting their money back.


For anyone that wants to learn more about Dentitox Pro can reach out to the customer service team by filling out a contact form at:



Dentitox Pro provides users with a boost to their oral health, making it easier to improve the oral climate within the mouth. This improvement is meant to keep the gums and teeth clean, reducing the risk of toxic bacteria that could otherwise ruin their immune system and cause bad breath. The ingredients used are entirely plant-based, which is incredibly beneficial on the user’s body.

More Like This: Steel Bite Pro Reviews: Risky Scam or Ingredients That Work?

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

How To Improve Your Gut Health – Forbes Health

How To Improve Your Gut Health – Forbes Health

  • June 17, 2021

You’ve probably heard the term “gut health” and know that “good” gut health is desirable. But what does it really mean to have a healthy gut? It means having the right balance of tiny bacteria and other microbes in your digestive tract. Researchers are increasingly discovering ways these microorganisms contribute to overall health.

“A healthy gut means you have a stronger immune system, a better mood, effective digestion that’s free of discomfort and a healthy brain and heart,” says Sabine Hazan, M.D., a gastroenterologist, founder of Ventura Clinical Trials in Ventura, California, and author of “Let’s Talk S—.”

5 Science-Backed Ways to Restore Gut Health

Certain foods and healthy lifestyle habits can improve your gut health naturally.

1. Eat Fiber-Rich and Probiotic-Packed Foods

Fiber is a plant-based nutrient that reduces the risk of metabolic diseases by stimulating the growth and diversity of good bacteria in the gut, research suggests. Sweet potatoes, spinach, beets, carrots and fennel are full of naturally gut-enhancing fiber. Besides fruits and vegetables, whole grains are a rich source of fiber, too. 

Fermented foods like yogurt, kimchi, sauerkraut and kombucha are also prized for their gut-boosting abilities, thanks to the presence of probiotics. Yogurt specifically may help calm gastrointestinal conditions like diarrhea, inflammatory bowel disease and constipation. One study found people who eat yogurt regularly have more lactobacilli, a gut-benefitting bacteria, in their intestines, as well as fewer enterobacterium, a type of bacteria linked with inflammation. 

2. Consider a Supplement

Probiotic supplements have become increasingly popular as word of the importance of gut health continues to spread. While probiotic supplements aren’t a panacea for gut health, there’s some evidence they can give the microbiota a boost and restore gut health under certain conditions.

Your doctor may also recommend a probiotic supplement if you’re prescribed an antibiotic. Evidence suggests this may help prevent antibiotic-associated diarrhea. 

If you’re interested in a probiotic supplement, talk to your doctor. While such supplements have a history of apparently safe use, especially in healthy people, the risk of harmful effects is greater in people with compromised immune systems. 

3. Exercise Often

Movement is medicine for so many parts of the human body, including the microbiome. In both animal and human studies, researchers have found that exercise promotes an increase in diversity of healthy bacteria in the gut.

While several studies highlight the roles exercise and diet can play together in positively impacting gut health, a 2019 review specifically reported that exercise has the potential to alter gut bacteria composition and functionality independently of diet. Researchers found longer workouts and high-intensity aerobic training, in particular, contributed most to gut bacteria diversity and function in relation to overall wellness. They also observed that lean people are more likely to reap the gut health benefits of exercise than individuals with overweight or obesity.

4. Limit Your Alcohol Intake

Drinking too much may negatively affect your microbiome, too. Repeated alcohol use is linked to gastritis, an irritation of the gut in which it becomes inflamed. Such inflammation can lead to heartburn, chronic discomfort, ulcers and bacterial infections. 

Drinking too much is also associated with intestinal inflammation, which is a sign of an unhealthy gut. Research suggests that this kind of inflammation alters the microbiota—including how well it works—and can throw it off balance. 

5. Reduce Stress Levels

Stress isn’t just mental: Think about those butterflies you feel when you’re excited or anxious. Experts in gut health often cite the “gut-brain connection” and refer to the gut as “the second brain.” While we don’t know everything about their relationship, we do know that mental health and the gut are intimately connected. 

Research suggests anxiety and depression are affected by the gut and vice versa—they can increase the risk of IBS, and people with IBS are more likely to experience these mental health disorders. 

Finding ways to manage your mental health and stress levels may help reduce uncomfortable GI symptoms and get your body back in balance. Don’t know where to start? Try adding some physical activity to your day. Something as simple as a daily walk might improve gut health, as research suggests exercise can increase the quality and quantity of health-boosting gut microbes.

Why Gut Health Matters

Your gut—otherwise known as your digestive system or your gastrointestinal (GI) system— digests the foods you eat, absorbs nutrients from it and uses those nutrients to fuel and maintain your body. 

“The gut plays a huge role in the health and well-being of our bodies,” says Alicia Romano, a specialized clinical dietitian at Tufts Medical Center in Boston and a spokesperson for the Academy of Nutrition and Dietetics. In addition to digesting food and absorbing nutrients, “the gut is in tight communication with the brain, playing a constant game of telephone and influencing a number of factors, including immune activity, GI muscle contractions and fluid secretion. And the gut is a key player in the body’s immune system—over 70% of your immune cells reside in the gut.”

About Your Microbiome

The microbiome is all of the bacteria, viruses and fungi that inhabit the human body, says Dr. Hazen.

These bacteria are everywhere, including the skin, mouth, throat, stomach, colon, uterus, ovarian follicles, prostate, lungs, ears and eyes. “You name it, and there are microorganisms nearby,” Dr. Hazen says, adding that research has identified around 10,000 different microbial species in the human body.

Microbiologists divide bacteria into two categories: aerobic, meaning they require oxygen, and anaerobic, meaning they don’t require oxygen. “Bacteria that live on the skin are aerobic while those that thrive in the gut are usually anaerobic,” Dr. Hazen explains. “The microbiome is the key; it influences all sorts of health conditions from cancer to COVID-19.”

Signs and Symptoms of an Unhealthy Gut

One less-than-pleasant sign something’s up with your gut? Unfamiliar changes in your poop.

“If you notice abrupt changes to your stool length, color or consistency, this may be cause for concern,” Dr. Hazen says. “Normal stool should be brown and never include blood.”

Because so much of the population experiences issues with their bowels during certain points of their lives, doctors developed the Meyers Scale (aka Bristol Scale) to help patients describe their poop “without bringing in colored photos,” Dr. Hazen says. Different numbers on the scale are associated with different bowel movement issues, so consider checking out the scale to help communicate your concerns to your physician. 

Still, it’s important to remember what’s considered normal to you. “If your poop has looked like Silly Putty your whole life and you don’t experience any pain, this could be your normal,” says Dr. Hazen, explaining that describing something as “normal” is all relative. 

Beyond the status of your bowel movements, there are other signs your gut could use some attention. While everyone needs to be concerned about their gut health, Dr. Hazen says, the following symptoms may signal that your gut health could use some attention. Schedule some time with your physician if you experience:

  • Abnormal weight loss
  • Anemia diagnosed by your doctor
  • Change/pain in bowel habits
  • Rectal bleeding 


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Restoring gut microbes can improve antibiotic-induced dysbiosis and prevent colitis in mice

Restoring gut microbes can improve antibiotic-induced dysbiosis and prevent colitis in mice

  • June 8, 2021

A new study at the University of Chicago has determined that restoring a single microbial species — Bacteroides sp. CL1-UC (Bc) — to the gut microbiome at a key developmental timepoint can prevent antibiotic-induced colitis in a mouse model of the condition. The results, published on June 7 in Gastroenterology, have major implications for humans dealing with inflammatory bowel disease (IBD), and underscore the impact of early childhood exposures on health throughout the lifetime.

Prior studies in human patients have found that early life exposure to antibiotics can skew the gut microbiome, causing dysbiosis, or an imbalance of the microbial populations in the gut, which is correlated with increase risk for developing pediatric IBD.

We know that the kinds of microbes that you’re exposed to early in life actually determine how your immune system develops. Our immune system learns to recognize our own selves, and the trillions of microbes in our gut — they’re ‘us’ as well, so our immune system has to learn to tolerate these organisms, just as it tolerates our own cells. Early exposure to antibiotics can eradicate some of the organisms that are essential for educating the immune system to develop immune tolerance.”

Eugene Chang, MD, Senior Author, Martin Boyer Professor of Medicine, UChicago

Due to the challenges of conducting such studies in human patients, the researchers opted to use a common model for studying colitis: mice that lack a gene known as IL-10 (IL-10-/-). “This mouse model has been established as being genetically susceptible to IBD, and we know that the gut microbiome plays a crucial role in the development of colitis in this model,” said first author Jun Miyoshi, MD, PhD, a Senior Assistant Professor in the Department of Gastroenterology and Hepatology at Kyorin University School of Medicine, and a former postdoctoral scholar at UChicago.

While only very rarely do these mice develop spontaneous colitis without any intervention in a clean environment, if their mothers are exposed to antibiotics during pregnancy and nursing, the disrupted microbiome can be transmitted to the pups at an early age. Around 30% of pups with this vertically transmitted disrupted microbiome go on to develop colitis.

The investigators used a technique known as shotgun metagenomic sequencing to screen the fecal microbiomes of IL-10-/- mice that had antibiotic-induced dysbiosis, alongside an untreated control group, and identify specific microbial species that might distinguish the two groups. This led them to members of the bacterial phylum Bacteroides.

One clue of the phylum’s importance was that Bacteroides was very abundant in the microbiomes of untreated mice, but completely lacking in the mice that had been exposed to antibiotics. What’s more, the researchers never saw Bacteroides in the treated mice that did not go on to develop colitis — but they often found Bacteroides in the guts of mice that did end up with the condition.

“These bacteria were eradicated by early exposure to antibiotics and were essential for educating the immune system in developing immune tolerance,” said Chang. “When those mice later acquired the bacteria, their immune system had never seen it. It was viewed as foreign, not as self, and their immune systems reacted to it.”

In an effort to determine whether restoring important Bacteroides back to the microbiome could correct the dysbiosis, the researchers honed in on a particularly abundant species known as Bacteroides sp. CL1-UC (Bc). They tried adding Bc back to the microbiomes of the mice with dysbiosis at two timepoints: around infancy (three weeks of age) and adulthood (11 weeks of age).

Engrafting Bc into the younger mice, during the critical immune system developmental window, corrected their dysbiosis and prevented colitis, but adding Bc back to adult mice could not correct the dysbiosis, and even worsened their colitis.

“This shows that you can’t just restore the missing bacteria at any time point, it has to be at a specific time early in life to have a beneficial effect,” said Chang. “In young animals, we know that the immune system is developing, it’s naive, it has to be taught, and it’s taught by being exposed to certain kinds of microbes. In some ways, it’s similar to a peanut allergy — early exposure to the antigen can tolerize the immune system to help avoid a peanut allergy, but it has to happen within a very finite window.”

The researchers were surprised to learn that restoring a single microbe was enough to correct lifelong dysbiosis, and said it highlighted how relatively small changes can have a dramatic impact on a system. “It’s like the tall trees of the Amazon rainforest,” said Chang. “You need the tall trees, because if you don’t have them, the ecosystem below cannot develop properly. But if you have those trees in place, the rest of the ecosystem will flourish.”

The results also go against popular theories on the origin of IBD. “There’s a misconception that colitis is caused by a classical pathogen, like salmonella, and scientists have spent years looking for a culprit,” said Chang. “But what our data are pointing to is that these diseases are caused by our own commensal microbes. They are present in the normal, healthy microbiome, but given the right circumstance and opportunity, they can transform into disease-promoting microbes.”

While this early study was proof-of-concept, if the results translate to humans, the ripple effects are likely to be far-reaching. “This shows that we probably have to rethink our approach to these kinds of complex immune disorders,” said Chang. “We can see that risk is developing early in life — even in utero — and so this has implications for practices such as C-sections and formula feeding, which can impact the microbes an infant is exposed to. What this says to me is that, as physicians, we need to shift our thinking to not what immediately preceeds these diseases but what happens early in life. That’s where we need to intervene for these patients.”


Journal reference:

Miyoshi, J., et al. (2021) Early-life microbial restitution reduces colitis risk promoted by antibiotic-induced gut dysbiosis in IL-10-/- mice. Gastroenterology.

Pirbright generates first pig flu antibodies to improve human treatments, guide flu vaccine selection

Pirbright generates first pig flu antibodies to improve human treatments, guide flu vaccine selection

  • June 7, 2021

This indicates they could be used to develop and assess human antibody therapies and their delivery methods. The pig antibodies also have the potential to improve how flu virus evolution is monitored and inform decisions about annual flu vaccine selection.

Antibodies form a vital part of the immune system’s response and help to fight off infections by latching on to important parts of invading microorganisms to neutralise them. In the case of flu viruses, many antibodies target a protein on the surface of the virus called haemagglutinin, which then prevents the virus from entering cells and replicating.

Pirbright scientists worked in collaboration with the University of Oxford, The Francis Crick Institute and The Pirbright Livestock Antibody Hub to generate pig antibodies in the laboratory (known as monoclonal antibodies, or mAbs). These are the first pig mAbs to be generated which target the influenza virus.

These mAbs recognise the same two main sites of the flu virus haemagglutinin protein that are targeted by human antibodies, and were found to be just as effective at neutralising the swine flu strain that caused the 2009 pandemic.

Dr Elma Tchilian, Mucosal Immunology Group Leader at Pirbright, said: “This demonstrates that pigs and humans, which are both natural hosts for influenza viruses, generate very similar immune responses.”

Pigs that were treated with one of the mAbs prior to infection were protected from severe disease and the flu virus was eliminated from their lungs. “These results indicate that the mAbs have therapeutic potential and could be used to evaluate mAb delivery methods” added Dr Tchilian.

Ferrets are commonly used as models to monitor flu virus evolution and to design or select vaccines that will provide the best protection against human seasonal flu strains. However, ferret antibodies did not recognise one of the main haemagglutinin sites that human antibodies target. The findings in the study, published in PLOS Pathogens, demonstrate that pig mAbs are more closely matched to human antibodies and could therefore improve the reliability of human vaccine selection.

Professor John Hammond, leader of The Pirbright Livestock Antibody Hub, added: “These results are a fantastic demonstration of how The Pirbright Livestock Antibody Hub can promote the use of new tools and methods, providing the opportunity to examine detailed antibody responses to inform the next generation of vaccines and therapies. This work reinforces the use of pigs as powerful model to predict human responses in infection and vaccination.”

This work was supported by the Bill & Melinda Gates Foundation and the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI).

Scientists from Oxford were also supported by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CIFMS), China Grant, the Townsend-Jeantet Prize Charitable Trust and the Medical Research Council (MRC, UKRI).

Scientists from The Francis Crick Institute were supported by Cancer Research UK, the Medical Research Council and the Wellcome Trust.

Alzheimers Q&A: How can you improve your memory? | Health/Fitness

Alzheimers Q&A: How can you improve your memory? | Health/Fitness

  • May 31, 2021

We all have lapses in memory, and the older we get the more common it is to forget someone’s name, misplace the car keys or miss appointments.

Genetics, aging and medical conditions all affect the brain and play roles in cognitive loss, but scientists have identified ways to minimize age-related changes and improve everyday memory function.

You can protect your memory by following a healthy diet, exercising regularly, keeping mentally active and socially engaged. Additionally, studies have shown that having positive beliefs about aging can improve memory performance in older adults.

A diet rich in Omega-3 fatty acids, fruits and vegetables, 8 ounces of fish weekly and walnuts and unsalted nuts are important in maintaining a “fit” brain and memory. Experts advise eating 80% of what you intend to at each meal and to eat with utensils so that you will eat less and pay attention to eating more healthy foods. You also should eat fewer processed foods. 

Aerobic exercise will help the heart and feed the brain with the oxygen. It also promotes cognitive functioning, such as memory, and is now believed to relate to positive structural changes in the brain. Walking 6 miles weekly, dancing, gardening, biking, and hiking all adding up to at least 150 minutes of exercise a week, help promote cognitive functions and reduces the risk of Alzheimer’s.

Maintain your social circle, building friendships and family relationships. Participation in social and community activities improves mood and memory function. Wait longer to retire. Socialization, not isolation, will stave off Alzheimer’s disease and dementia-related disorders.

Mental workouts are essential, and challenging the mind can help it grow and expand, which may improve memory. Learn something new like a second language or how to play a musical instrument. Take up a new hobby. Read. Write. Do things with your nondominant hand. Play board games or do puzzles. Travel to new places.

Also, monitor your stress levels and sleep habits. Incidences of higher stress and lack of sleep can contribute to loss of memory and can impede the brain’s ability to perform at optimum level.

Slow down your hurried life. Meditate and practice relaxation techniques such as deep breathing and muscle relaxation. Praying on a daily basis can enhance your immune system. Participate in regular worship.

Identify what your stressors are and how they affect you and identify ways to handle them. In a society where everyone feels they have to constantly multitask, don’t be afraid to say no.

The memory snags that occur normally during older age are subtle and do not have to interfere with daily life. In fact, you can easily adapt to them by making lists, establishing routines, using associations and employing memory aids.

Questions about Alzheimer’s disease or related disorders can be sent to Dana Territo, the Memory Whisperer, owner of Dana Territo Consulting, LLC, at

Researchers develop “cell encapsulation” technology to stimulate immunity to fight cancer

New study may help improve stem cell transplantation, lead to better drugs

  • May 29, 2021

Your immune system is always busy fighting incoming threats. It consists of a system of cells, and when there is a shortage of cells, it affects the performance of the immune system.

This is seen in e.g. cancer patients following chemotherapy. This is because chemotherapy targets all the cells in your body, including the stem cells in your bone marrow, which were meant to develop into new immune cells. This means that the immune system then lacks cells to fight new infections.

There are drugs that can harvest stem cells from the bone marrow, so that they can be returned to the patients after treatment. They then develop into new immune cells, enabling the body to once again fight incoming threats. But previously, we lacked detailed knowledge of how these drugs worked.

Now, a study conducted in mice by researchers at the University of Copenhagen demonstrates how the medicine works at the cell level – and, surprisingly, how one of the two applied and tested drugs is more effective than the other, despite the fact that the other drug, on paper, appears to be the most effective of the two. This discovery may not just help improve stem cell transplantation; it may also lead to improved drugs in the future.

We have tested two drugs for stem cell transplantation which appear to have the same effect. What they do is block a receptor, causing the bone marrow to release stem cells into the blood. What the new study shows, though, is that they do not just block the receptor; one of the two drugs also affects other signalling pathways in the cell. And in short, that makes it more effective than the other of the two drugs.”

Astrid Sissel Jørgensen, PhD Student, Department of Biomedical Sciences, University of Copenhagen

“We used to believe that all we had to do was block the receptor, and that the two drugs had the same effect. It now appears that there is more to it,” she says.

The drugs tested by the researchers mobilize stem cells by acting as CXCR4 receptor antagonists. This means that they inhibit or reduce activity of the receptor. Several drugs target this receptor, including drugs inhibiting HIV replication.

“The drugs not only block the receptor’s normal signalling. One of the two drugs we have tested also affect some of the other cell pathways and even make the receptor withdraw into the cell and disappear from the surface,” explains Professor Mette Rosenkilde, who is the corresponding author of the study. The study results reveal that one of the two drugs makes the bone marrow release more stem cells into the blood.

This knowledge about how drugs affect cell pathways differently is also known as biased signalling. And it is things like these that make one of the drugs more effective in practice than on paper.

According to the researchers, the new knowledge on biased signalling challenges our current view of these drugs.

“The results of our study directly influence our view of drugs used for stem cell transplantation. In the long term, though, it may also affect our view of future drugs, and how new drugs should be designed to have the best possible effect, both in connection with stem cell mobilisation, but also for treating HIV infections, where this particular receptor also plays a main role,” says Mette Rosenkilde.


Journal reference:

Jørgensen, A. S., et al. (2021) Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization. Communications Biology.

Person getting vaccinated.

Tips to improve our immune response after vaccination against COVID-19 – Explica .co

  • May 29, 2021

Vaccines are one of the health measures that have provided the greatest benefit to humanity. They have made it possible to prevent diseases responsible for major epidemics throughout history, such as smallpox.

Just over a year ago, COVID-19 was added to this list. Today we need vaccination again to be able to stop the spread of the coronavirus and regain normalcy.

Available vaccines have been shown to be effective in preventing the disease. However, the magnitude and quality of the immune response to vaccines varies considerably between individuals.

They are several factors that can influence in response to a vaccine.

Some refer to individual characteristics, such as age, sex, their genetic information and the presence of other pathologies (such as diabetes and cardiovascular diseases, both linked to alterations in the immune system).

But, in addition, our immune response to vaccines can vary depending on daily practices in our day to day.

What habits can improve our immune response after vaccination?

One of the key factors to promote the proper functioning of our immune system is sleeping a sufficient number of hours, as well as controlling our stress level.

Correct sleep hygiene allows to properly maintain biorhythms that control the production of hormones that regulate the function of the immune system, such as melatonin.

This hormone is produced during the night and its administration has been linked to lymphocyte survival and increased antibody production.

In fact, several studies have shown how insufficient sleep hours, both in the days before and after vaccination, can reduce the effectiveness of vaccines.

Stressful situations promote the release of hormones that suppress immune function, like cortisol, and are associated with a decreased response to vaccination.

Alternatively, activities that provide us satisfaction, such as sports or social relationships, favor the release of hormones that stimulate the immune system, such as endorphins.

Consistent with this idea, individuals who regularly exercise moderately and in a positive mood at the time of vaccination develop an increased response of antibodies and other immune response-enhancing molecules (such as cytokines).

Person getting vaccinated.Our immune response to vaccines can vary depending on our daily practices. (Photo: Getty Images)

The importance of eating well

Another crucial aspect to improve the effectiveness of a vaccine is to have an optimal nutritional status. There are several nutrients whose link with the immune system has been scientifically proven.

This is the case of vitamin C and folic acid, both with an important role in the production of effective molecules against infection.

Also the creation of collagen, which contributes to the maintenance of our natural barriers against pathogens.

However, studies suggest that isolated nutrient deficiencies appear to have little impact on response to vaccines, whereas a balanced diet, with a balanced supply of energy, seems to be key to strengthening the immune system.

In fact, people with high body mass indexes, and even obese, have lower production of antibodies, T lymphocytes and cytokines after vaccination.

It is also worth considering the relationship between the gut microbiota and responses to vaccines.

The microbiota associated with the intestinal tract plays key roles in protecting against the invasion of pathogenic microbes and regulating the immune system.

This microbiota is home to millions of microorganisms, mainly bacteria from the Firmicutes and Bacteriodetes groups.

The composition of said microbiota is relatively stable, and under normal conditions it presents a greater abundance of Firmicutes, which is associated with a greater antibody response.

donutsdonutsA balanced diet, with a balanced intake of energy, seems to be key to strengthening the immune system. (Photo: Getty Images)

Antibiotics, tobacco and alcohol

However, some circumstances, such as the existence of some pathology, changes in diet or the use of antibiotics, can produce alterations in the microbiota that affect our response to vaccination.

In these situations, the consumption of probiotics that restore balance in our intestinal microbiota has shown potentially beneficial effects on the response to vaccination, although it seems to vary according to the bacteria used, the dose or the duration of administration.

Finally, tobacco use directly alters our line of defense in the respiratory mucosa, and has been associated with lower antibody production after receiving vaccines.

Likewise, excessive alcohol consumption has an undesirable immunosuppressive effect when we receive a vaccine; Furthermore, alcohol can alter the composition of our intestinal microbiota and the immune cells present there, favoring the entry of pathogens into our body.

The immune response to vaccination is variable in the population.

Some of the factors that can influence it correspond to daily habits that affect our immune status, and knowing them can help us to modify them in order to boost our immune system so that it responds effectively when we get vaccinated.

* Patricia López Suarez is a professor at the toImmunology Area of ​​the University of Oviedo. This artThe article originally appeared on The Conversation. You can read the original version here.

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Improve Your Children’s Immunity Levels

Improve Your Children’s Immunity Levels

  • May 27, 2021


Image: Shutterstock

The second wave of coronavirus is causing a surge in cases and are said to be quite scary for the kids too-who have been largely spared during the pandemic.  At a time when children do not have access to COVID vaccines, how can parents keep them safe from the newer virus strains and waves by boosting their kid’s immunity? Functional nutritionist Mugdha Pradhan, founder of iThrive tells us more about what parents can do to increase their children’s immunity.


What Lowers Immunity?

To build a child’s immunity, it is essential to first comprehend the factors that lower their immunity. These factors include nutritional deficiencies, accumulation of toxins, imbalance in the gut microbiome, eating too many inflammatory foods, exposure to electromagnetic fields, lack of deep sleep, movement scarcity, lack of sunlight exposure, and last but not the least, stress.



Image: Shutterstock

Nutritional Precautions

As a parent, it is your duty to ensure that your child’s everyday diet is rich in various essential nutrients such as proteins, glucose, saturated fat, omega-3 fatty acids, vitamin D, magnesium, vitamin B complex, iodine, iron, etc. It is also important to necessitate an overall transformation in the child’s daily food consumption. In order to build a robust immune system, it is essential to eliminate/ reduce processed sugar, refined flours, processed foods, seed oils, sugary drinks, caffeine in the everyday diet.

Increase the consumption of good quality protein such as eggs, pulses, and sprouts in a young one’s diet. Cut down the intake of harmful fats and increase the consumption of good saturated fat. It is also necessary to inculcate the habit of eating seasonal fruits in children on a daily basis and Increase the consumption of whole grains that are rich in essential fibre. It is also advisable to address the daily nutritional requirement of children by giving them a good quality supplement to replace essential nutrients that might not be available from food



Image: Shutterstock

Building Up Gut Health

Yes, if children have poor gut health or digestive issues, they are naturally susceptible to any viral or bacterial attacks. This is, essentially, because 70 per cent of your immune system is located in your gut and is overtly responsible when it comes to streamlining the body’s immune response. The most revealing data shows that there’s an immune system of gut microbes working together, communicating with your body to sound the alarm when a spike in defence is needed. A healthy gut microbiome is a vital key to your child’s overall wellness.


Caring For Children’s Health

Besides maintaining a healthy diet, it is also important to ensure various other aspects of your kid’s life safeguard them from the virulent pathogen. Make it a rule that your child spends at least an hour everyday day in sunlight (sunlight exposure boosts the immune system) and there is some outdoor play and activity involved. You can also identify spaces around your home as the chances of infections in open outdoor spaces with fresh air are minimal. Being outdoors in the lap of nature allows your children to get a healthier microbiome environment.

Lastly, rest is most essential for an effective immune system. You must permit your child enough time to sleep, re-evaluate their daily schedule and salvage 10-12 hours of sleep every night.


Also read: Superfoods For Increasing Your Child’s Immunity 

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Meditation Can Lower Stress and Improve Physical Health

Meditation Can Lower Stress and Improve Physical Health

  • May 26, 2021

The key to lowering stress levels — and reaping those health benefits — lies in calming the sympathetic branch of our autonomic nervous system (responsible for our body’s fight-or-flight response) and activating our parasympathetic nervous system, which helps return our body to a calm stage. Focusing on the breath, and learning to slow it down, can lower stress hormones. It’s taught to veterans with PTSD, in corporate settings, pain clinics, prisons and anywhere else stress levels are high (i.e., practically everywhere these days).

5 short breathing exercises

1. Focused breathing. Concentrative meditation involves focusing on a single point. It could be a visual image (say, a picture of a flower or the flickering flame of a candle), a sound or the sensation of your own breath. One technique Gordon recommends is called soft belly breathing. Sit in a comfortable chair. With your eyes closed, breathe slowly and deeply. Focus on the breath coming in through your nose and going out through your mouth, with your belly soft and relaxed. “You can say the word ‘soft’ to yourself as you breathe in and ‘belly’ as you breathe out,” says Gordon. When a stray thought pops into your head — and it will — acknowledge it, then let it pass, bringing yourself back to the present moment. You can do this exercise for 10 minutes, five minutes, or even three minutes.

2. Slower breathing. Try slowing your breath even more. If you normally inhale for three seconds and exhale for three seconds, try increasing that to four seconds in and four seconds out. Another technique is to stay at three seconds when inhaling but slowly increase your exhales to four, five or even six seconds. “Inhalation is tied more to the sympathetic nervous system, exhalation to the parasympathetic nervous system,” says Timothy McCall, a board-certified physician specializing in internal medicine and author of Yoga as Medicine: The Yogic Prescription for Health and Healing. “So if you start to increase the exhalation relative to the inhalation, it tends to be more calming.”

3. Mantra repetition. While doing a deep-breathing exercise, repeat a word or a sound. It could be anything — om, one, peace, love. For those who are religious, it might be a prayer. One of McCall’s favorite mediations, sohum mantra meditation, comes from yoga. “This is a meditation based on the sound your breath makes when it comes into your nose and when it leaves your nose,” says McCall. “That’s what the ancient yogis thought they could hear upon inhalation (so) and on exhalation of (hum). You’re not making those sounds — you’re listening for sounds with each inhalation and exhalation.”

4. Alternate nostril breathing. A 2013 study found that people who practiced this technique not only lowered their stress levels, their cardiovascular function improved. How to do it: Close your eyes. Use the thumb of your right hand to block your right nostril, and inhale deeply through the left for six seconds. Now cover your left nostril with the fourth finger of your right hand, release your right nostril, and exhale slowly for six seconds. With your left nostril blocked, breathe in through your right side for six seconds; cover your right nostril again, release your left and exhale for six seconds. Repeat for at least two minutes.

5. Body scan. This technique can be helpful for chronic pain or to simply release tension. Lie on your back, eyes closed, breathing slowly. Allow your mind to move up your body — from toe to foot to ankle, and through the rest of your body. Bring attention to each part of your body, being aware of any sensations, then let it go and move on. If you notice pain, acknowledge it and gently breathe through it.

Probiotics improve aerobic capacity and reduce stress in athletes

Probiotics improve aerobic capacity and reduce stress in athletes

  • May 25, 2021

Prolonged and intense exercise may have the potential to suppress the immune system, and impair sports performance​. Clinical evidence has also shown that strenuous training may induce anxiety and stress​ as well as having a potential impact on gastrointestinal health​. 

The benefits of taking probiotics to improve sports performance have been showcased by many investigators​. In terms of their impact on the psychological health of athletes, many studies have focused on the effects of probiotics on healthy volunteers but limited studies have been conducted on competitive athletes.

Hence, this study was designed to determine the effects of daily probiotic supplementation on anxiety, stress, mood and fitness levels among competitive badminton players.

This intervention was a randomised, placebo-controlled study involving 30 badminton players aged 18 to 30 from Universiti Teknologi MARA (UiTM) in Shah Alam, Malaysia. Participants were randomly divided into a probiotic group (PG, Lactobacillus casei​ at a dose of 3 × 1010 cfu mixed with orange juice) and a control group (CG, orange juice) and were given daily treatments for six weeks. 

Tests were undertaken before intervention and after the six weeks. Body parameter data was collected using an InBody 500 bioelectrical impedance analyse, food intake was recorded using three-day records, and anxiety level was determined using the revised competitive state anxiety inventory​ (CSAI-2R). A 20-minute multi-stage shuttle run test was used to measure aerobic capacity fitness, a handgrip test and a vertical jump test measured hand and leg strength, and a 40-minute dash and t-test measured speed and agility.