4 Best Testosterone Boosting Supplements - Top Natural Boosters for Increasing Testosterone Levels

4 Best Testosterone Boosting Supplements – Top Natural Boosters for Increasing Testosterone Levels

  • January 22, 2021

Testosterone is the main male hormone. It is an anabolic steroid that is responsible for the development of the male sex organs in the puberty stage. This hormone increases strength, muscle mass, and sex drive. It also decreases fat mass and gives an athletic body. While the levels of testosterone are the highest during early manhood and decrease with progressing age. So, many men have low testosterone levels and experience many health conditions like erectile dysfunction, loss of muscle mass, gain in fat mass, reduced energy, low sexual desire, and depression.

So, there is a need for extra testosterone in men that according to the medical experts can be obtained from testosterone supplements. Artificial steroids have many harmful effects and cause many health disorders. But some natural testosterone booster supplements have natural ingredients and can provide extra energy, sex drive, and an athletic body like the youthful days. There are two natural supplements available in the market now that can effectively boost up testosterone levels safely.

Why Should Men Use Testosterone Boosters?

With advancing age, the natural testosterone production in men decreases. The man gains fat mass and loses his muscle mass. He starts losing his sex drive and starts experiencing sexual disorders like erectile dysfunction and low stay power. Visiting clinics are costly and the medicines prescribed have long-term side effects. In contrast, some of the natural supplements that are available in the market to boost testosterone levels are safe, effective, and affordable. After research on the available testosterone booster supplements, the author has found the two best ones that are reviewed for the readers.

Top 4 Natural Testosterone Booster Supplements

  1. Testogen
  2. TestoMax
  3. TestoFuel
  4. Prime Male

Testosterone is a chief and important hormone in the body of a male. It’s crucial to have optimum production of the specified hormone in the human body if a person wishes to develop muscle mass. As men start aging, their body generates very little testosterone which destroys the overall structuring of the body. Their nature of sexual functions and life also gets diminished. This is why all people need a testosterone booster such as Testogen and Testo Max. These supplements are made up of all-natural high-quality ingredients. So, they don’t give artificial and synthetic testosterone to the human body such as steroids. The supplement facilitates the generation of the crucial and chief male hormone that provides the consumers with better recovery of muscles. The product also provides the user’s body with much-needed energy.

Firstly, this product review addresses the characteristics of the Testogen supplement, how it works, the components used in the product, and its advantages on the human body.

1. Testogen

  • Its chief role is to develop the user’s muscle mass. It stimulates the optimum generation of testosterone in the human body.
  • It gives the human body much-required energy to execute day-to-day tasks after going through an extreme workout session.
  • The company of the Testogen supplement offers the users a 100-day money-back policy.

Testogen Natural and Strong Testosterone Booster

This is an organic testosterone booster that has become the best seller in a few years. It contains effective ingredients that can boost up testosterone production, increase libido, and muscle mass. It contains very powerful and effective natural ingredients that can detoxify the body and boost-up the testosterone production from inside.

Ingredients

  • D-Aspartic Acid  – D-Aspartic Acid regulates amino acids that help to generate testosterone.
  • Vitamin D3– Vitamin D3 increases testosterone levels in the body.
  • Magnesium – Magnesium generates testosterone by enhancing the enzymes. This is required for the production of the hormone.
  • Extract of Korean Red Ginseng – This component stimulates the libido which improves the user’s mood and gives him stronger and harder erections.
  • Extract of Nettle Leaf  – Extract of Nettle Leaf helps to release testosterone from its beholden form. The sex hormone Binding Globulin is also released with testosterone to increase libido.
  • Vitamin K1 – Vitamin K1 makes human bones healthier and stronger. Stronger bones can suck up Vitamin D in a better way. This increases testosterone levels.
  • Extract of Fenugreek – This component helps in improving the overall strength and stamina of the user’s body. The seed of Fenugreek increases the testosterone levels of the body.
  • Zinc – Zinc helps to increase the levels of testosterone in the human body naturally.
  • Vitamin B6 – This Vitamin helps in growing androgens. Androgens are a very vital and crucial hormone. This increases the testosterone levels in the body. This hormone is extremely important in the male reproductive system.
  • Bioperine – Bioperine helps in absorbing all the components present in the supplement effectively.
  • Boron – Boron helps in identifying and treating erectile dysfunction. It improves both muscle and bone strength.

More Information on Testogen Can Be Found On The Official Website Here

How to Use Testogen?

While steroidal injections pump in artificial testosterone hormone in the body, Testogen contains natural ingredients that boost up the natural production of testosterone. To balance the testosterone levels in the body, the company recommends 4 capsules daily with a glass of water with breakfast. The company claims that if taken with breakfast, the user will be full of energy the whole day and work out hard in the gym.

How Does the Testogen Work?

Testogen is manufactured with all-natural ingredients. This makes it the best selling product. These components present in the product safely enhance the levels of testosterone in the body. This does not contain any synthetic ingredients or products that can harm the body. Testogen enhances the whole system of the human body and stimulates the body to generate more and more testosterone in the body. People who have low testosterone levels in the body can use this product. This supplement balances the hormone levels in the body safely. According to the manufacturers of Testogen, regularity in consuming the supplement will give faster favorable results.

(LOWEST PRICE ONLINE) Click Here to Buy Testogen From The Official Website

Pros 

  • Improves your testosterone levelsThe supplement improves the hormone levels in the body. The combination of all the ingredients would boost the production of testosterone in the body. This will increase the testosterone levels in the body.
  • Contains all-natural ingredients The product has 100% all-natural ingredients that work effectively and helps the human body in numerous ways. This product does not have chemicals or artificial additives. This helps in keeping the body healthy and active. This provides the user with all the benefits naturally.
  • Helps in building musclesIt gives the user’s lean muscles that the user wanted to get. It will provide the customer with these benefits without even going to the gym. The supplement helps to build lean muscles.
  • Helps lose stubborn fatTestogen enhances the levels of testosterone in the body. This helps in improving the metabolic system of the body. It helps the user in losing stubborn and accumulated excess fats in the body in any troublesome areas.
  • Improves the moodLow testosterone levels in the body affect a person’s mood drastically. A bad mood gets any person irritated very quickly. Testogen improves the user’s mood and changes the user’s bad mood into a delightful one.
  • Increases the libido – People having problems with their sex drive and sex life can use Testogen. This will help them increase their self-confidence and enhance libido.
  • Easy useThe supplement is in pill formulation. So, it is very easy to consume compared to the other testosterone-boosting supplements in the entire market.
  • Fast resultsThe user will be able to see noticeable results in just 14 days of starting to consume the supplement. The user can see visible results if the user takes the suggested dosage regularly.
  • No side effects The supplement is manufactured by using all-organic components. So, the supplement does not have any side effects. This supplement does not harm the body in any way.

Cons 

  • Only available on their websiteThe user can buy the supplement from their authentic, official website. They offer worldwide user shipping. If the user wants to get the best deals, the user will have to purchase it from the website.
  • Strict dosage The user should follow the suggested dosage to have the desired results.

Reasons to Purchase Testogen

The user should purchase this supplement to get benefits in both the overall health and hormone levels. Testogen is made up of high-quality all-natural ingredients. This ingredient naturally boosts the production of the hormones and enhances testosterone levels. The supplement also contains potent ingredients that reduce symptoms of joint discomfort and boosts the immune system.

Head Over To The Official Testogen Website Using This Link

2. Testo Max 

  • The supplement is an organic formulation that works effectively for young, middle-aged, and old males.
  • It helps males to develop muscle mass. This also helps in getting stronger.
  • The product helps in melting accumulated extra fat from the human body, particularly the belly fat.
  • Testo Max helps in controlling blood pressure. It also helps in overcoming fatigue.
  • The developer affirms that Testo Max can enhance testosterone levels by more than 40% in less than 2 weeks of starting to use the product in regular dosage.

(HUGE SAVINGS TODAY) Click Here to Get Testo Max Supplement For The Lowest Price Right Now

Testo Max The Safe Natural and Effective Testosterone Booster

Muscle building becomes difficult as natural testosterone levels decrease with age. So, with hours of work out in the gym also, men cannot gain muscle mass. Here, supplementation with a natural and safe dietary supplement called Testo Max will naturally boost testosterone levels. Men take this supplement to easily sustain the workout and get an increased muscle mass and lean fat-free body. The seller claims that men who have erectile dysfunction and low-libido can benefit hugely from this natural testosterone booster.

Ingredients

Testo Max has 12 natural ingredients that are effective in boosting the natural production of testosterone.

  • Vitamin B6 – The human body doesn’t have only the hormones estrogen and testosterone. It also has a very important androgen, a precursor that helps boost the blood’s T-hormone level. Vitamin B6 enhances androgen levels in the body by instructing the body to boost up production. This Vitamin also improves the mood that is required by men suffering from low testosterone levels that gives rise to depression and mood swings.
  • Vitamin D3 – This is an essential vitamin found in sunlight, but many are deficient in it. Research proves that men who are deficient in Vitamin D have hormone imbalances, including testosterone deficiency. So the manufacturers have included a big boost of this useful Vitamin so that the testosterone levels remain healthy.
  • Vitamin K2 – Vitamin K2 is an important constituent of this supplement that balances all the body hormones. It signals the brain to increase testosterone production so that sex drives increase. It also helps in removing ED or erectile dysfunction. in
  • D-Aspartic Acid – This is an important amino acid that acts as a neurotransmitter. It boosts the testosterone level, increases sperm count, and improves fertility.
  • Zinc – This mineral regulates the functioning of the pituitary gland so that healthy levels of the male hormone testosterone is secreted. It also improves immunity and prevents the onset of age-related diseases.
  • Magnesium – It reduces the SHGB count in the blood which is responsible for low absorption of testosterone hormone. By reducing the SHGB in the blood, magnesium increases the free flow and absorption of the testosterone hormone. This also gives the body a boost of energy to sustain rigorous bodybuilding exercises.
  • Ginseng – Medical use of Ginseng has been done from ancient days. This is a powerful antioxidant that improves the immunity and overall lifespan of the user. It improves all bodily functions and also prevents diseases like erectile dysfunction and low libido.
  • Mucuna Pruriens – The main reason for lower T-levels is high estrogen in the bloodstream. Mucuna Pruriens is a source of levodopa, an amino acid boost testosterone level improves the addition of muscle mass to give lean muscles easily. It also decreases the accumulated fat in the body and gives a slim and manly body structure.
  • Luteolin – It is a potent aromatase inhibitor. This works on the aromatase, and also reduces the excess estrogen from the blood. It balances estrogen and testosterone levels perfectly so that the body gets to use the male hormone. Even in men above 50, this component gives an enhanced sex drive, high energy levels, and a youthful lean body.
  • Nettle Root – It has many health benefits, so the formulators have included it in Testo Max. This root extract allows the free availability of testosterone in the blood.
  • Boron – This is known to have a positive effect on the working of testosterone. It improves the functionality of the male hormone, reduces inflammations and joint pains by nurturing healthy bones and cartilages.
  • BioPerine – Bioperine is a very important component that allows the easy processing of nutrients. The formulators use it to improve the effectiveness of Testo Max. It can also improve protein levels and lean muscle formation.

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How to Use Testo Max

The manufacturers advise the users to consume 4 capsules daily with a glass of water with the morning meal or before the exercise schedule to get an extra boost of energy.

How Does Testo Max Work?

This supplement boosts testosterone production from inside the body by improving the functioning of the pituitary gland. It also contains ingredients that increase energy levels, sex drive, immunity, and muscle mass. It also

Pros

  • It gives very high energy levels throughout the day.
  • It gives more strength to the body for sustaining more bodybuilding activities.
  • Improves libido and cures erectile dysfunction.
  • Makes the user happy and removes anxiety and depression
  • Improves immunity and prevents diseases like prostate cancer.

Cons

  • The effect of this natural supplement is fast but not miraculous like a steroidal injection.

Why should the users buy?

The users should buy Testo Max to boost energy levels, increase muscle mass, and improve the sexual drive. Available steroids boost the testosterone levels very fast but have side effects like physical and psychological changes and lead to prostate cancer. Testo Max is a natural alternative that improves immunity, muscle mass, aids fat-loss, improves libido, and joint health. Even older men benefit hugely from Testo Max as it enhances performance and reduces recovery time.

Click here to Get the Best Deal on Testo Max from the Official Website

3. Testofuel

  • Its main role is to help build muscle mass in men by facilitating the optimal production of testosterone in the body.
  • It also provides the body with much-needed energy to perform day-to-day activities after an intense workout session.
  • The company offers a 90-day refund guarantee.

Testofuel is one of the most effective muscle-building supplements available in the market. It has emerged to become the most trusted supplement in its industry. Users across America have been getting positive results from using the product as it helped them gain muscle mass. Men have been experiencing results from supplementing Testo fuel with their diet that indeed gives them the required energy to carry out an intense gym session and allows better muscle recovery.

As per the creators, it’s one of the safest supplements in the market. They have only used pure and potent substances in the composition. All the constituents are plant-based and work in sync to increase the production of testosterone in a male’s body.

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Listed below are the main ingredients used in the composition of Testofuel:-

  • Fenugreek: It’s a naturally occurring herb found in the Mediterranean conditions. It has a sweet aroma and is used in Asian cuisine. It’s rich in zinc, selenium, and magnesium, three of the micronutrients most people are deficient in. The herb helps inhibit the sex hormone-binding globulin (SHBG) which is responsible for taking up the most amount of the testosterone produced. And, as the herb puts brakes on this hormone, it becomes easier for the “free” testosterone to work.
  • D-Aspartic Acid: It’s a significant amino acid that aids in the regulation of testosterone synthesis, helps in building muscle mass, and the production of growth hormone. A recent study says that men who consumed a regular dose of the supplement increased their testosterone levels by 8-10%
  • Vitamin D: This micronutrient is extremely important for male hormones and so it’s named the sixth steroid. Even though it’s obtained from the UV rays, it’s scarce for men living in the West. This is where the supplement helps. The micronutrient can optimize testosterone production in the body.
  • Asian Red Panax Ginseng: It’s an Asian herb that is known to improve mood patterns and improve cognitive abilities. It also helps in building the immune system of the body. It’s a libido enhancer and has direct impacts on testosterone levels.
  • Extract of Oyster: It’s an ancient food used to enhance libido in the body. It’s an aphrodisiac that has high-zinc content and can easily elevate the testosterone levels in the body.
  • Vitamin B6: “B” vitamins are probably the most important category of vitamins there is. Vitamin B6 is also called pyridoxine and it promotes physical and mental well-being. This Vitamin is known to reduce the production of the primary female hormone estrogen and boost testosterone production.

There are other ingredients as well like vitamin K2, Magnesium, and Zinc. Readers can find the entire list of ingredients on the official website of the company.

How Does Testofuel Work?

As per the website of the manufacturer, they have used pure and potent forms of substances that are naturally occurring in nature. They are tested so that the constituents can work in sync to increase the production of testosterone in the body. The creators emphasize that the supplement doesn’t provide testosterone artificially to the body, like some steroids, but helps optimize its production in the body. It’s a known fact that if someone wants to bulk, their body’s production of testosterone must be optimal. More production of testosterone induces better post-workout recovery and also provides energy.

Dosage

One bottle of Testofuel contains 120 pills and each bottle is a one-month supply, so according to that, users must take 4 pills every day.

Pros 

  • It helps users to develop muscle mass.
  • The supplement enhances the production of testosterone in the body.
  • It gives the body more energy to push through an intense workout session.
  • Testofuel promotes better muscle recovery.
  • It improves the user’s mood and cognitive abilities.
  • The supplement can also boost the immune system of the body.
  • There’s a 90-day refund guarantee backing the product.

Cons

Where to Buy the Supplement and What are the Available Packages?

Users can visit the official website of the seller and see the available packages. They can order the package that’s most suited to their requirements. One box of Testo fuel is available for $65, two boxes $130, and three for $195. The company offers free shipping for orders across the US and the UK. They have also backed the product with a 90-day money-back guarantee, so customers can return the supplement if they want, and get a refund.

Click here to Get the Best Deal on TestoFuel from the Official Website

4. Prime Male

  • It’s a natural formula that works for young and old men.
  • It helps men build muscle mass and get stronger.
  • The supplement helps shed excess fat from the body, especially from the belly region.
  • Prime Male helps control blood pressure levels and helps overcome fatigue.
  • The seller claims that it can boost testosterone levels by 42% in only 12 days of consuming a regular dose of the supplement.

Prime Male is one of the most popular muscle-building supplements available in the market. It’s formulated by Roar Ambition Ltd., a trusted supplement company based in the UK. Just like all their other supplements, the creators have used natural substances to formulate the product. They claim that the proprietary blend used by them is ideal for mature men.

As per the website of the manufacturer, the supplement will help boost testosterone production in the body. It’s made with an all-natural formulation under the supervision of experts and doctors. Each ingredient is tried and tested for purity and potency before being added to the composition.

Given below are the major ingredients used in the composition of the supplement-

  • D-Aspartic Acid: An important amino acid, D-Aspartic acid helps in facilitating muscle growth. It also helps regulate testosterone in the body and use it for carrying out important activities. It’s a safe substance that boosts the production of testosterone by 12% in the short-term.
  • Zinc: Most men are unaware that they are probably deficient in this micronutrient. This is because to optimize testosterone production in the body, zinc is absolutely necessary. And, if people want to get the necessary amount of zinc from foods, they would have to eat a lot. This supplement, therefore, helps users cover the daily intake and optimizes testosterone production.
  • Vitamin D3: Another micronutrient that helps regulate testosterone production in the body, vitamin D3 intake is quite important. Everyone knows that the sun is the primary source of vitamin D3 but the amount obtained isn’t adequate and the supplement addresses it.
  • Vitamin K2: A micronutrient known to work simultaneously with vitamin D3. It helps vitamin D3 get absorbed quickly and also optimizes ‘T’ levels in the body. The creators use Menaquinone-7 in the composition of the supplement which happens to be an enhanced version of vitamin K2.
  • Ashwagandha Extract: It’s an ancient herb used to treat sexual problems. It’s also known to alleviate tension and stress from the mind which helps in improving the sexual performance of the user. Many studies indicate that it can enhance testosterone levels as it reduces anxiety but more importantly, ashwagandha gives energy to the user for an intense workout session.
  • Luteolin: as much as optimizing the production of testosterone is important, reducing the build-up of the primary female hormone, estrogen, is just as necessary. Luteolin does just that, inhibiting the production of estrogen.
  • Boron: Boron helps in maintaining the balance between hormones in the body. It can reduce inflammation and improve bone health in the body. Boron inhibits the growth of sexual hormone-binding globulin (SHBG), a hormone that needs to be stopped to increase testosterone production.

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How Does Prime Male Work?

There’s a simple working for every testosterone booster out there in the market. First, the ingredients used in the supplement need to get absorbed in the bloodstream of the individual. When it gets assimilated, Prime Male works to optimize the production of testosterone in the body. Greater testosterone levels ensure better recovery of muscles. And, it facilitates an increase in muscle mass. The supplement also contains ingredients that are known to increase the energy levels in the body, which aid people to push through an intense workout session.

How to Use Prime Male?

Every Prime Male bottle contains 120 pills of the testosterone-boosting supplement. For the best results, users must take 4 capsules of the supplement every day. Users may take 2 pills before their workout session and 2 at night before going to sleep.

Pros

  • The company claims that they have used naturally occurring substances in the composition of the supplement to formulate it.
  • It can boost testosterone production in the body by 40-45% in only a few weeks of using it.
  • The supplement helps in better muscle recovery, thereby aiding muscle growth.
  • The seller offers free shipping for all orders from the UK and the US.
  • It provides extra energy to the users for them to carry out intense workouts in the gym.

Cons

  • The supplement can be purchased only from the official website of the company.

Pricing Policy

There are four packages of the supplement available on the company’s website. Users can visit the website and choose the most suitable package for themselves. The one-month package is available for $65, two-month supply for $130, four-month supply for $195 (one bottle is complimentary), and six-month package for $260 (two bottles complimentary).

Symptoms of Low Testosterone

Any person can understand if their testosterone levels are low if their body shows any of the following signs:

  1. Fat Accumulation– Accumulation of fat despite exercising and following a good diet.
  2. Decreased Muscle Mass– Although muscle mass decreases with age, if it happens at an alarming rate despite exercising and following a good diet, the reason can be low testosterone levels.
  3. Mood Swings– The reason for mood swings is associated with change in hormonal levels.
  4. Decreased Libido– Testosterone is the sex hormone in males, the lack of which results in decreased libido.

Click here to Get the Best Deal on Prime Male from the Official Website.

Working of Testosterone Boosters

The work of testosterone boosters is to help the body produce more testosterone. They lower the levels of estrogen and prolactin and thus, help in the release of testosterone. All this is possible with the help of special ingredients that are combined together in specific ratios to make an effective formula.

Advantages of Testosterone Boosters

  • Improved Mood
  • Improved Sex Drive
  • Better Muscle Mass
  • Improved Bone Density
  • Improved Blood Circulation

Conclusion

The levels of testosterone drop when a person hits the 30s and the signs of decreasing testosterone levels result in the inability to build muscle mass and accumulate fat. It is better, then, to opt for a testosterone booster that contains natural ingredients so that there is no risk of side effects. These boosters should be taken after consulting a physician, especially if the user is on medications and the dosage followed should always be that recommended by the manufacturer.

Prevent bird flu with this natural and ayurvedic tips

Prevent bird flu with this natural and ayurvedic tips

  • January 21, 2021

New Delhi: Bird flu, also called avian influenza, has come as a double whammy for countries that are already fighting their biggest battle against Covid-19. Again, the sign and symptoms are related to the respiratory system only along with fever. Since there is not much clarity about its complications and other issues which patients can face, there is no one way to deal with this situation.

As per the available data and as a general rule of Ayurveda strength of diseases can be reduced by only good immunity. So, the best way to protect yourself from any kind of disease is to boost your immunity and follow a healthy lifestyle which can go beyond opting good eating habits. Daily routine, waking up early morning and sleeping on time are also part of a healthy lifestyle.

With work-from-home in place, people now-a-days tend to work over night resulting in a disturbed sleep cycle. Such lifestyles affect our immunity and various ‘doshas’ of the body, says Dr. Pooja Kohli.

“So, first of all we all need to follow a healthy lifestyle which includes a healthy meal on time, sound sleep, daily exercise & meditation, offering food for our mind as well as soul,” says Kohli who is the Vice President of Ayurveda Growth at NirogStreet.

To keep your immune system in shape and strengthen body’s fighting mechanism she suggests these simple yet impactful tips to follow.

Give that extra herbs touch: You can add a few herbs like Ginger, garlic, turmeric in your daily diet to avoid bird flu kind of infections. These herbs give strength to the body for fighting back and also protect our body from getting infected.

Best Prebiotic Supplement With Natural Ingredients

  • January 20, 2021

NEW YORK, Jan. 20, 2021 /PRNewswire/ — Peak BioBoost Probiotic is a natural supplement that enables a person to poop daily effortlessly and without pain. Constipation is a common problem that many people around the world face. Such scenarios give stomach pain and other symptoms that could provide a person with discomfort. If a person cannot poop every day or firmly, then there is a gut problem. Furthermore, when there is a problem with the gut, it leads to worse bowel issues. The one who is suffering from the same issue, it is a high time to take instant action to avoid the worst situation.

As per the Peak BioBoost Probiotic manufacturer, the formula targets the inner cause of constipation and effectively gives excellent results. People usually wonder why constipation takes place? When there is a slow process of peristalsis, it leads to dry and more problematic poop. Peristalsis is a process of muscle contraction where the food moves around the intestines and leaves it in the form of poop. If there is a slow muscle contraction, it sucks the water from the intestines and leaves harder poop. When such a scenario happens, it results in constipation, bloating, and lousy gas farts. Usually, when a person is on medication or having a stress issue, it makes the situation worse. Ageing is also a factor of constipation and gas formation.

Creators of Peak BioBoost Probiotic found that when there is a better speed of sluggish bowels, it solves the problem. To treat such problems, it is important to take instant action. The product, Peak BioBoost, is natural and does not contain any chemicals or harmful substances. The manufacturer also claims that it is a scientifically proven formula to poop daily without any pain and smelly gas. This probiotic helps maintain a healthy gut lining, betters the digestion, and upgrades the  immune system. The product provides essential fibre for a better digestive system and enhances beneficial bacteria to poop quickly.

REPORT IN THE OFFICIAL WEBSITE: https://www.mypeakbiome.com/

The product is packed with natural ingredients, such as prebiotic ghost fibre, XOS, Inulin, Acacia Gum, FOS, and Flax seeds. Prebiotic Ghost fibre is a significant ingredient of Peak BioBoost, and it is responsible for relaxing the nerves. Ghost fibre helps in accelerating the stool movement and enhances the good bacteria present in the gut. XOS allows a natural increase of already present prebiotic in the body. Inulin is a dietary fibre that enhances gut health. Acacia gum is responsible for reducing bloating and gas. Flax Seeds are a fibre that improves the digestive system and strengthens the immune system. MUST SEE: “Shocking New Peak BioBoost Report – This May Change Your Mind”

These natural ingredients work together to make the formula more effective and powerful. As per the manufacturer, the procedure works in four different ways, and the first one is it relaxes the muscles for better gripping of intestines. Then, it accelerates the stool movements through the intestines. Next working is, the formula softens the stool, and last but not least, the product offers better gut health with good bacteria. It is a formula that enables a person to get rid of constipation naturally and without depending on medicines.

Peak BioBoost Prebiotic is relatively popular among users due to its quick and effective results. The manufacturer says that the product comes with numerous benefits starting from better and firmly poop regularly to reduce stress. The supplement also helps in enhancing heart health, sleep pattern, mood patterns. By consuming the formula, a person will feel lighter and experience less bloating. Peak BioBoost Prebiotic ensures good bacteria in the stomach for a more robust digestive system and healthy gut. Also, the product is safe to use as it does not include any artificial substance.

Manufacturer of Peak BioBoost prebiotic provides a 100% money-back guarantee. Also, there are few discount offers present on its official site in regards to its purchase. The process of taking this prebiotic is simple; all a user has to do is add one scoop of powder every morning to coffee or tea.

According to the creator, one can add the powder to pancakes, salads, protein drinks, and smoothies. In today’s time, constipation problems are increasing due to unhealthy eating habits. In this, a natural Peak BioBoost is a promising dietary supplement, helping you lead a comfortable daily life.

Official Website: https://www.mypeakbiome.com/

Contact Details:
Peak BioBoost
[email protected]
Toll Free: 1-800-390-6035

SOURCE Peak BioBoost

Natural and ayurvedic tips to prevent bird flu

Natural and ayurvedic tips to prevent bird flu : The Tribune India

  • January 19, 2021

New Delhi, January 19

Bird flu, also called avian influenza, has come as a double whammy for countries that are already fighting their biggest battle against Covid-19.

Again the sign and symptoms are related to the respiratory system only along with fever. Since there is not much clarity about its complications and other issues, which patients can face, there is no one way to deal with this situation.

As per the available data and as a general rule of Ayurveda strength of diseases can be reduced by only good immunity. So, the best way to protect yourself from any kind of disease is to boost your immunity and follow a healthy lifestyle which can go beyond opting good eating habits. Daily routine, waking up early morning and sleeping on time are also part of a healthy lifestyle. 

With work-from-home in place, people now-a-days tend to work over night resulting in a disturbed sleep cycle. Such lifestyles affect our immunity and various ‘doshas’ of the body, says Dr. Pooja Kohli. “So, first of all we all need to follow a healthy lifestyle which includes a healthy meal on time, sound sleep, daily exercise & meditation, offering food for our mind as well as soul,” says Kohli who is the Vice President of Ayurveda Growth at NirogStreet.

To keep your immune system in shape and strengthen body’s fighting mechanism she suggests these simple yet impactful tips to follow. 

Give that extra herbs touch: You can add a few herbs like Ginger, garlic, turmeric in your daily diet to avoid bird flu kind of infections. These herbs give strength to the body for fighting back and also protect our body from getting infected.

Nasya to keep your respiratory system in shape: Every morning putting two to four drops of Anu tail in each nostril will give strength to the respiratory system, this therapy is known as Nasya. This also helps in flushing out pollutants or foreign bodies from the nasal cavity and prevents them from crossing the nasal pathway. 

Remove toxins with oil pulling therapy, gargling and steam inhalation: One of the other important therapy is oil pulling therapy, it can be done by holding lukewarm oil in the mouth for a few seconds followed by gargling with lukewarm water with a pinch of salt and turmeric along with steam inhalation. Oil pulling therapy, gargling and steam inhalation helps in removing toxins and boost immunity of the person.

Start your morning with one spoon of Chyawanprash: One more important add on in daily life is Chyawanprash. Every morning during breakfast taking one spoon of Chyawanprash helps in boosting immunity and strengthens respiratory system. 

Golden Milk: Before sleeping, taking golden milk (Milk with sugar and pinch of turmeric) is one of the best remedies to get rid of symptoms like fever, cold and running nose etc.

IANS

Representative Image

Natural And Ayurvedic Tips To Prevent Bird Flu

  • January 19, 2021
New Delhi:

Bird flu, also called avian influenza, has come as a double whammy for countries that are already fighting their biggest battle against Covid-19. Again the sign and symptoms are related to the respiratory system only along with fever. Since there is not much clarity about its complications and other issues which patients can face, there is no one way to deal with this situation.

As per the available data and as a general rule of Ayurveda’s strength is diseases can be reduced by only with good immunity. So, the best way to protect yourself from any kind of disease is to boost your immunity and follow a healthy lifestyle which can go beyond opting good eating habits. Daily routine, waking up early morning and sleeping on time are also part of a healthy lifestyle.

With work-from-home in place, people now-a-days tend to work over night resulting in a disturbed sleep cycle. Such lifestyles affect our immunity and various ‘doshas’ of the body, says Dr. Pooja Kohli.

“So, first of all we all need to follow a healthy lifestyle which includes a healthy meal on time, sound sleep, daily exercise & meditation, offering food for our mind as well as soul,” says Kohli who is the Vice President of Ayurveda Growth at NirogStreet.

To keep your immune system in shape and strengthen body’s fighting mechanism she suggests these simple yet impactful tips to follow.

Give that extra herbs touch: You can add a few herbs like Ginger, garlic, turmeric in your daily diet to avoid bird flu kind of infections. These herbs give strength to the body for fighting back and also protect our body from getting infected.

Nasya to keep your respiratory system in shape: Every morning putting two to four drops of Anu tail in each nostril will give strength to the respiratory system, this therapy is known as Nasya. This also helps in flushing out pollutants or foreign bodies from the nasal cavity and prevents them from crossing the nasal pathway.

Remove toxins with oil pulling therapy, gargling and steam inhalation: One of the other important therapy is oil pulling therapy, it can be done by holding lukewarm oil in the mouth for a few seconds followed by gargling with lukewarm water with a pinch of salt and turmeric along with steam inhalation. Oil pulling therapy, gargling and steam inhalation helps in removing toxins and boost immunity of the person.

Start your morning with one spoon of Chyawanprash: One more important add on in daily life is Chyawanprash. Every morning during breakfast taking one spoon of Chyawanprash helps in boosting immunity and strengthens respiratory system.

Golden Milk: Before sleeping, taking golden milk (Milk with sugar and pinch of turmeric) is one of the best remedies to get rid of symptoms like fever, cold and running nose etc.

10 Natural Ways to Detox and Boost Your Immunity at Home

10 Natural Ways to Detox and Boost Your Immunity at Home

  • January 14, 2021

Toxins enter the body through what we eat, drink, breathe in, and process in any way. Once inside, toxins overtax our immune system and detoxification system and leave us more vulnerable to illness — not ideal during cold and flu season, and especially not this year during a pandemic — and make us age a little faster, too.


Fortunately, there are a lot of simple things you can do from the comfort of your own home to keep toxins out of your body, flush them out of your system faster, and boost your immunity all at the same time, says Dr. Bill Rawls, Medical Director of Vital Plan. He shares his top 10 strategies below.

1. Source Your Food Wisely

Try to stay away from packaged and processed foods that contain ingredients you can’t pronounce, and instead reach for fresh food from natural sources. Aim to make vegetables more than 50% of your daily diet — their fiber is a great natural binder, and they’re full of beneficial phytochemicals — and minimize your red meat consumption.

Also, whenever practical, choose organic over conventional products. That said, we know organic prices and accessibility can be an issue, so for help making strategic decisions, refer to the Environmental Working Group (EWG) “Dirty Dozen” and “Clean Fifteen” lists:

The Dirty Dozen:

  1. Strawberries
  2. Spinach
  3. Kale
  4. Nectarines
  5. Apples
  6. Grapes
  7. Peaches
  8. Cherries
  9. Pears
  10. Tomatoes
  11. Celery
  12. Potatoes
  13. Raisins*

(*While raisins aren’t technically a fresh food, the EWG found that they are “one of the dirtiest produce commodities on the market — and even some organic raisins are contaminated.”)

The Clean Fifteen

  1. Avocado
  2. Sweet corn
  3. Pineapple
  4. Onion
  5. Papaya
  6. Frozen sweet peas
  7. Eggplant
  8. Asparagus
  9. Cauliflower
  10. Cantaloupe
  11. Broccoli
  12. Mushrooms
  13. Cabbage
  14. Honeydew
  15. Kiwi

2. Consider Detoxifying and Immune-Boosting Herbs

There are a number of herbs and natural ingredients that can help support detoxification and immune health. Here are the ones at the top of Dr. Rawls’ list:

Chlorella: This nutrient-rich freshwater algae binds to toxins so they can be eliminated from your body more efficiently. Chlorella works particularly well for withdrawing heavy metals. Pure chlorella can be purchased in the form of bulk powder, tablets, or capsules.

Milk Thistle: It’s been used for thousands of years to support a healthy liver, the primary organ responsible for detoxification.

Dandelion: Known to help support liver function, research suggests dandelion helps promote the body’s natural detoxification and elimination processes.

Bitters: Bitter flavors are important to digestion — they stimulate the release of the saliva, enzymes, and bile that help break down your food. Include bitter herbs and foods in each meal, or take a botanical extract that blends bitter herbs like dandelion root, burdock root, orange peel, and gentian root

Reishi mushroom: An extensively studied adaptogenic mushroom, reishi has exceptional immunomodulating and antiviral properties. It helps normalize inflammatory cytokines and promotes healthy immune response against threatening microbes.

Rhodiola: Another adaptogen, rhodiola improves stress tolerance by reducing fatigue, supporting energy levels, and improving tissue oxygenation.

Turmeric: This popular spice is well loved for its anti-inflammatory and antioxidant properties.

Shilajit: An herbo-mineral adaptogen, shilajit has a long history of use in traditional Indian medicine for longevity and strength. It’s also an immunomodulator with antioxidant, anti-inflammatory, and antiviral properties.

Gotu Kola: Best known for improving memory and mood, gotu kola is also great for promoting a normal response to inflammation, balancing stress hormones, and supporting circulation.


Shop Vital Plan Pure Chlorella

Vital Plan is a certified B Corporation — one of only eight supplement companies recognized for achieving the highest standards of social and environmental performance, accountability, and transparency. If you make a purchase using the link above, EcoWatch may earn a commission.

3. Filter Your Water

Much of America’s tap water has been shown to contain pollutants, so filtering what comes out of your kitchen sink is smart. To be sure you’re using a filter that does the trick, keep these guidelines in mind:

  • Look for a filter certified by NSF International or the Water Quality Association.
  • Choose one that removes the contaminants in your water (check your local drinking water quality report to see what’s present).
  • Change your water filters on time.

4. Choose Safe and Effective Cleaning Supplies

When buying household cleaning products, don’t bring home chemicals that could harm your health more than some of the microbes you’re trying to get rid of. Fortunately, there are a number of products on the market that work safely; here are some ways to shop wisely:

  • Look for the Green Seal, Ecologo, or Safer Choice (EPA) seals.
  • Opt for fragrance-free options.
  • Avoid triclosan and quaternary ammonium compounds or “quats.” (One tactic is to choose products that don’t advertise as “antibacterial.”)
  • Consult the EWG’s list of safe and effective products for guarding against coronavirus.

5. Opt for Non-Toxic Beauty and Personal Care Products

There are a lot of claims made on beauty and self-care products these days, but words alone, like “natural,” “organic,” “non-toxic,” “clean,” “green,” and “eco-friendly,” don’t mean a thing — they aren’t backed by any sort of regulatory or certification processes. Instead, to find non-toxic products you trust, you have to do a little research.

Start by checking reputable ratings databases like Skin Deep (EWG) and Think Dirty. Another good bet: Look for reliable third-party certifications on products labels, including:

  • USDA Organic
  • EWG Verified
  • Made Safe
  • NSF/ANSI 305
  • Natural Products Association Certified
  • Whole Foods Market Premium Body Care

6. Get Outside

One more reason to get outdoors beyond combatting cabin fever: The air in natural environments is generally much cleaner than indoor air. For one, outdoor air contains ⅔ less carbon dioxide, high levels of which negatively affect our productivity, sleep, and more.

Forest air in particular contains phytoncides, organic compounds emitted by trees and plants that have been shown to boost our immune system function, plus plants in general help neutralize toxic substances in the air. Forests, open spaces, and open water are also rich in negative ions, which reduce inflammation.

So take your pick of natural environs, and get out there as often as possible — while still maintaining at least 6 feet of distance between yourself and others, of course.

7. Bring Nature Indoors

Plants are natural air purifiers, so bringing some plants indoors can help clear the air in your home. Here’s a list of the top 10 air-purifying plants to consider:

  • Areca palm
  • Lady palm
  • Bamboo palm
  • Rubber plant
  • Dracaena
  • English ivy
  • Dwarf date palm
  • Ficus
  • Boston fern
  • Peace lily

8. Drive Less, Move More

Staying off the roads decreases air pollution, and the fact that many of us are driving less these days is noticeably improving air quality. If your commute is on hold, try to translate some of your usual travel time into getting more physical activity, or sneak in more movement between other normal routines.

Exercise improves circulation, oxygenates your tissues, and enhances the work of the lymphatic system through muscle contractions — all of which make it easier to move toxins out of your body.

9. Practice Forgiveness

Through the practice of gratitude, we stay centered and in the present moment. This allows us to move through situations from our heart. Take time to forgive someone or yourself for things in the past. When we forgive, we expand and open up to endless possibilities.

10. Quit a Bad Habit

Are you a smoker? Pack rat? Chronically sleep-deprived? In a bad relationship? Toxins come into our lives in many forms. Consider if you’re participating in any unhealthy patterns or holding onto anything that no longer serves you, and then find a way to limit those things in your life.

Dr. Rawls is a licensed medical doctor in North Carolina and a leading expert in integrative health. He has extensive training in alternative therapies, and is the Medical Director of Vital Plan, a holistic health and herbal supplement company in Raleigh, NC.

Reposted with permission from Vital Plan.

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Children's immune response more effective against COVID-19 -- ScienceDaily

Boosting a natural cellular process could reduce damage, study suggests — ScienceDaily

  • January 12, 2021

An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is likely to cause further lung damage.

In a new study, scientists identified a molecule that is produced by immune cells during mechanical ventilation to try to decrease inflammation, but isn’t able to completely prevent ventilator-induced injury to the lungs.

The team is working on exploiting that natural process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators. Delivering high levels of the helpful molecule with a nanoparticle was effective at fending off ventilator-related lung damage in mice on mechanical ventilation.

“Our data suggest that the lungs know they’re not supposed to be overinflated in this way, and the immune system does its best to try to fix it, but unfortunately it’s not enough,” said Dr. Joshua A. Englert, assistant professor of pulmonary, critical care and sleep medicine at The Ohio State University Wexner Medical Center and co-lead author of the study. “How can we exploit this response and take what nature has done and augment that? That led to the therapeutic aims in this study.”

The work builds upon findings from the lab of co-lead author Samir Ghadiali, professor and chair of biomedical engineering at Ohio State, who for years has studied how the physical force generated during mechanical ventilation activates inflammatory signaling and causes lung injury.

Efforts in other labs to engineer ventilation systems that could reduce harm to the lungs haven’t panned out, Ghadiali said.

“We haven’t found ways to ventilate patients in a clinical setting that completely eliminates the injurious mechanical forces,” he said. “The alternative is to use a drug that reduces the injury and inflammation caused by mechanical stresses.”

The research is published today (Jan. 12, 2021) in Nature Communications.

Though a therapy for humans is years away, the progress comes at a time when more patients than ever before are requiring mechanical ventilation: Cases of acute respiratory distress syndrome (ARDS) have skyrocketed because of the ongoing COVID-19 pandemic. ARDS is one of the most frequent causes of respiratory failure that leads to putting patients on a ventilator.

“Before COVID, there were several hundred thousand cases of ARDS in the United States each year, most of which required mechanical ventilation. But in the past year there have been 21 million COVID-19 patients at risk,” said Englert, a physician who treats ICU patients.

The immune response to ventilation and the inflammation that comes with it can add to fluid build-up and low oxygen levels in the lungs of patients already so sick that they require life support.

The molecule that lessens inflammation in response to mechanical ventilation is called microRNA-146a (miR-146a). MicroRNAs are small segments of RNA that inhibit genes’ protein-building functions — in this case, turning off the production of proteins that promote inflammation.

The researchers found that immune cells in the lungs called alveolar macrophages — whose job is to protect the lungs from infection — activate miR-146a when they’re exposed to pressure that mimics mechanical ventilation. This action makes miR-146a part of the innate, or immediate, immune response launched by the body to begin its fight against what it is perceiving as an infection — the mechanical ventilation.

“This means an innate regulator of the immune system is activated by mechanical stress. That makes me think it’s there for a reason,” Ghadiali said. That reason, he said, is to help calm the inflammatory nature of the very immune response that is producing the microRNA.

The research team confirmed the moderate increase of miR-146a levels in alveolar macrophages in a series of tests on cells from donor lungs that were exposed to mechanical pressure and in mice on miniature ventilators. The lungs of genetically modified mice that lacked the microRNA were more heavily damaged by ventilation than lungs in normal mice — pointing to miR-146a’s protective role in lungs during mechanical breathing assistance. Finally, the researchers examined cells from lung fluid of ICU patients on ventilators and found miR-146a levels in their immune cells were increased as well.

The problem: The expression of miR-146a under normal circumstances isn’t high enough to stop lung damage from prolonged ventilation.

The intended therapy would be introducing much higher levels of miR-146a directly to the lungs to ward off inflammation that can lead to injury. When overexpression of miR-146a was prompted in cells that were then exposed to mechanical stress, inflammation was reduced.

To test the treatment in mice on ventilators, the team delivered nanoparticles containing miR-146a directly to mouse lungs — which resulted in a 10,000-fold increase in the molecule that reduced inflammation and kept oxygen levels normal. In the lungs of ventilated mice that received “placebo” nanoparticles, the increase in miR-146a was modest and offered little protection.

From here, the team is testing the effects of manipulating miR-146a levels in other cell types — these functions can differ dramatically, depending on each cell type’s job.

“In my mind, the next step is demonstrating how to use this technology as a precision tool to target the cells that need it the most,” Ghadiali said.

The collaborative work by researchers in engineering, pulmonary medicine and drug delivery was conducted at Ohio State’s Davis Heart and Lung Research Institute (DHLRI), where Englert and Ghadiali have labs and teamed with Ohio State graduate students and co-first authors Christopher Bobba from the MD/PhD training program and Qinqin Fei from the College of Pharmacy to lead the studies.

Additional Ohio State co-authors include DHLRI investigators Vasudha Shukla, Hyunwook Lee, Pragi Patel, Mark Wewers, John Christman and Megan Ballinger; Carleen Spitzer and MuChun Tsai of the College of Medicine; and Robert Lee of the College of Pharmacy. Rachel Putman of Brigham and Women’s Hospital in Boston also worked on the study.

The research was supported by grants from the National Institutes of Health and the Department of Defense, and an Ohio State Presidential Fellowship.

Natural Killer Cells Could Play Key Role in Fight Against MM

Natural Killer Cells Could Play Key Role in Fight Against MM

  • January 12, 2021

Corresponding author Tony Reiman, MD, of the University of New Brunswick, and colleagues, explained that a wide array of emerging therapies, such as proteasome inhibitors, immunomodulatory drugs, and novel combination therapies, have significantly improved outcomes in patients with MM, but that the high rate of eventual relapse and the heterogeneity of the disease among patients have made it a particularly difficult cancer to fight.

“Additionally, MM is considered a disease of the immune system,” the investigators wrote. “Gradual immune dysregulation and impairment of NK cells, T cells, B cells, and dendritic cells allow malignant plasma cells to escape immunosurveillance.”

Reiman and colleagues proposed that a better understanding of the immune environment of MM could lead to strategies to reengage the immune system to inhibit MM growth. This is where NK cells potentially come into play.

These cells are considered the most active subset of innate lymphoid cells. Their name comes from their ability to target infected and malignant cells without prior sensitization. They cells have both activating and inhibitory receptors (IRs), and their activity is controlled by signals between the receptors.

One strategy for leveraging NKs is to use monoclonal antibodies to target IRs. This approach has shown benefits in other types of cancers, the authors wrote, and there is emerging evidence suggesting it is a viable option in MM as well.

They advocated paying particular attention “to understanding the heterogeneity of ligand expression both within and across patients with MM, the interplay between NK and T cells in response to IR blockade therapy, and how NK-targeted therapy can be combined with existing therapeutic options in MM patients.”

The authors said notable research has been published suggesting a role for several other IRs in MM biology: KIRs, NKG2A, TIGIT, TIM-3, PD-1, and LAG-3.

Of those, Reiman and colleagues singled out KIRs as the “most promising” target.“Not only were anti-KIR antibodies shown to be well tolerated, but they were also shown to enhance NK cell function,” they wrote.

Some of those IRs are also expressed on T cells, meaning therapies that target those receptors might boost the anticancer effects of both types of cells; however, the authors said most studies into the IRs have focused almost exclusively on T cells while ignoring NK cells.

Early failure of some clinical trials of IR blockades is likely due to intra- and interpatient heterogeneity, the authors noted. Any kind of IR-blockade therapy would likely need to be tailored to each particular patient’s expression of receptors, the investigators said, similar to what is done in solid tumors.

The investigators closed with a list of key steps they believe will need to be undertaken to bring NK-based therapy for MM close to fruition. Among those steps:

  • Profile NK cell receptors, subpopulations, cell activity, and cell function in MM
  • Profile the expression of NK cell receptor cognate ligands
  • Explore the integration of NK cell–based therapies and traditional therapies preclinically in order to optimize clinical trial design.

Reference

Alfarra H, Weir J, Grieve S, Reiman T. Targeting NK cell inhibitory receptors for precision multiple myeloma immunotherapy. Front Immunol. Published online November 12, 2020. doi:10.3389/fimmu.2020.575609

Boosting a natural cellular process could lower ventilator-related lung damage

Boosting a natural cellular process could lower ventilator-related lung damage

  • January 12, 2021

An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is likely to cause further lung damage.

In a new study, scientists identified a molecule that is produced by immune cells during mechanical ventilation to try to decrease inflammation, but isn’t able to completely prevent ventilator-induced injury to the lungs.

The team is working on exploiting that natural process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators. Delivering high levels of the helpful molecule with a nanoparticle was effective at fending off ventilator-related lung damage in mice on mechanical ventilation.

Our data suggest that the lungs know they’re not supposed to be overinflated in this way, and the immune system does its best to try to fix it, but unfortunately it’s not enough. How can we exploit this response and take what nature has done and augment that? That led to the therapeutic aims in this study.”


Dr. Joshua A. Englert, Study Co-lead Author, Assistant Professor, Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Wexner Medical Center

The work builds upon findings from the lab of co-lead author Samir Ghadiali, professor and chair of biomedical engineering at Ohio State, who for years has studied how the physical force generated during mechanical ventilation activates inflammatory signaling and causes lung injury.

Efforts in other labs to engineer ventilation systems that could reduce harm to the lungs haven’t panned out, Ghadiali said.

“We haven’t found ways to ventilate patients in a clinical setting that completely eliminates the injurious mechanical forces,” he said. “The alternative is to use a drug that reduces the injury and inflammation caused by mechanical stresses.”

The research is published today (Jan. 12, 2021) in Nature Communications.

Though a therapy for humans is years away, the progress comes at a time when more patients than ever before are requiring mechanical ventilation: Cases of acute respiratory distress syndrome (ARDS) have skyrocketed because of the ongoing COVID-19 pandemic. ARDS is one of the most frequent causes of respiratory failure that leads to putting patients on a ventilator.

“Before COVID, there were several hundred thousand cases of ARDS in the United States each year, most of which required mechanical ventilation. But in the past year there have been 21 million COVID-19 patients at risk,” said Englert, a physician who treats ICU patients.

The immune response to ventilation and the inflammation that comes with it can add to fluid build-up and low oxygen levels in the lungs of patients already so sick that they require life support.

The molecule that lessens inflammation in response to mechanical ventilation is called microRNA-146a (miR-146a). MicroRNAs are small segments of RNA that inhibit genes’ protein-building functions – in this case, turning off the production of proteins that promote inflammation.

The researchers found that immune cells in the lungs called alveolar macrophages – whose job is to protect the lungs from infection – activate miR-146a when they’re exposed to pressure that mimics mechanical ventilation. This action makes miR-146a part of the innate, or immediate, immune response launched by the body to begin its fight against what it is perceiving as an infection – the mechanical ventilation.

“This means an innate regulator of the immune system is activated by mechanical stress. That makes me think it’s there for a reason,” Ghadiali said. That reason, he said, is to help calm the inflammatory nature of the very immune response that is producing the microRNA.

The research team confirmed the moderate increase of miR-146a levels in alveolar macrophages in a series of tests on cells from donor lungs that were exposed to mechanical pressure and in mice on miniature ventilators. The lungs of genetically modified mice that lacked the microRNA were more heavily damaged by ventilation than lungs in normal mice – pointing to miR-146a’s protective role in lungs during mechanical breathing assistance. Finally, the researchers examined cells from lung fluid of ICU patients on ventilators and found miR-146a levels in their immune cells were increased as well.

The problem: The expression of miR-146a under normal circumstances isn’t high enough to stop lung damage from prolonged ventilation.

The intended therapy would be introducing much higher levels of miR-146a directly to the lungs to ward off inflammation that can lead to injury. When overexpression of miR-146a was prompted in cells that were then exposed to mechanical stress, inflammation was reduced.

To test the treatment in mice on ventilators, the team delivered nanoparticles containing miR-146a directly to mouse lungs – which resulted in a 10,000-fold increase in the molecule that reduced inflammation and kept oxygen levels normal. In the lungs of ventilated mice that received “placebo” nanoparticles, the increase in miR-146a was modest and offered little protection.

From here, the team is testing the effects of manipulating miR-146a levels in other cell types – these functions can differ dramatically, depending on each cell type’s job.

“In my mind, the next step is demonstrating how to use this technology as a precision tool to target the cells that need it the most,” Ghadiali said.

Source:

Journal reference:

Bobba, C.M., et al. (2021) Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation. Nature Communications. doi.org/10.1038/s41467-020-20449-w.

Hospital Ventilator

Boosting a Natural Cellular Process to Protect Lungs From Ventilator-Induced Injury

  • January 12, 2021

Hospital Ventilator

Research Suggests Boosting a Natural Cellular Process Could Reduce Damage

An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is likely to cause further lung damage.

In a new study, scientists identified a molecule that is produced by immune cells during mechanical ventilation to try to decrease inflammation, but isn’t able to completely prevent ventilator-induced injury to the lungs.

The team is working on exploiting that natural process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators. Delivering high levels of the helpful molecule with a nanoparticle was effective at fending off ventilator-related lung damage in mice on mechanical ventilation.

“Our data suggest that the lungs know they’re not supposed to be overinflated in this way, and the immune system does its best to try to fix it, but unfortunately it’s not enough,” said Dr. Joshua A. Englert, assistant professor of pulmonary, critical care and sleep medicine at The Ohio State University Wexner Medical Center and co-lead author of the study. “How can we exploit this response and take what nature has done and augment that? That led to the therapeutic aims in this study.”

The work builds upon findings from the lab of co-lead author Samir Ghadiali, professor and chair of biomedical engineering at Ohio State, who for years has studied how the physical force generated during mechanical ventilation activates inflammatory signaling and causes lung injury.

Efforts in other labs to engineer ventilation systems that could reduce harm to the lungs haven’t panned out, Ghadiali said.

“We haven’t found ways to ventilate patients in a clinical setting that completely eliminates the injurious mechanical forces,” he said. “The alternative is to use a drug that reduces the injury and inflammation caused by mechanical stresses.”

The research is published today (January 12, 2021) in Nature Communications.

Though a therapy for humans is years away, the progress comes at a time when more patients than ever before are requiring mechanical ventilation: Cases of acute respiratory distress syndrome (ARDS) have skyrocketed because of the ongoing COVID-19 pandemic. ARDS is one of the most frequent causes of respiratory failure that leads to putting patients on a ventilator.

“Before COVID, there were several hundred thousand cases of ARDS in the United States each year, most of which required mechanical ventilation. But in the past year there have been 21 million COVID-19 patients at risk,” said Englert, a physician who treats ICU patients.

The immune response to ventilation and the inflammation that comes with it can add to fluid build-up and low oxygen levels in the lungs of patients already so sick that they require life support.

The molecule that lessens inflammation in response to mechanical ventilation is called microRNA-146a (miR-146a). MicroRNAs are small segments of RNA that inhibit genes’ protein-building functions — in this case, turning off the production of proteins that promote inflammation.

The researchers found that immune cells in the lungs called alveolar macrophages — whose job is to protect the lungs from infection — activate miR-146a when they’re exposed to pressure that mimics mechanical ventilation. This action makes miR-146a part of the innate, or immediate, immune response launched by the body to begin its fight against what it is perceiving as an infection — the mechanical ventilation.

“This means an innate regulator of the immune system is activated by mechanical stress. That makes me think it’s there for a reason,” Ghadiali said. That reason, he said, is to help calm the inflammatory nature of the very immune response that is producing the microRNA.

The research team confirmed the moderate increase of miR-146a levels in alveolar macrophages in a series of tests on cells from donor lungs that were exposed to mechanical pressure and in mice on miniature ventilators. The lungs of genetically modified mice that lacked the microRNA were more heavily damaged by ventilation than lungs in normal mice — pointing to miR-146a’s protective role in lungs during mechanical breathing assistance. Finally, the researchers examined cells from lung fluid of ICU patients on ventilators and found miR-146a levels in their immune cells were increased as well.

The problem: The expression of miR-146a under normal circumstances isn’t high enough to stop lung damage from prolonged ventilation.

The intended therapy would be introducing much higher levels of miR-146a directly to the lungs to ward off inflammation that can lead to injury. When overexpression of miR-146a was prompted in cells that were then exposed to mechanical stress, inflammation was reduced.

To test the treatment in mice on ventilators, the team delivered nanoparticles containing miR-146a directly to mouse lungs — which resulted in a 10,000-fold increase in the molecule that reduced inflammation and kept oxygen levels normal. In the lungs of ventilated mice that received “placebo” nanoparticles, the increase in miR-146a was modest and offered little protection.

From here, the team is testing the effects of manipulating miR-146a levels in other cell types — these functions can differ dramatically, depending on each cell type’s job.

“In my mind, the next step is demonstrating how to use this technology as a precision tool to target the cells that need it the most,” Ghadiali said.

Reference: 12 January 2021, Nature Communications.
DOI: 10.1038/s41467-020-20449-w

The collaborative work by researchers in engineering, pulmonary medicine and drug delivery was conducted at Ohio State’s Davis Heart and Lung Research Institute (DHLRI), where Englert and Ghadiali have labs and teamed with Ohio State graduate students and co-first authors Christopher Bobba from the MD/PhD training program and Qinqin Fei from the College of Pharmacy to lead the studies.

Additional Ohio State co-authors include DHLRI investigators Vasudha Shukla, Hyunwook Lee, Pragi Patel, Mark Wewers, John Christman and Megan Ballinger; Carleen Spitzer and MuChun Tsai of the College of Medicine; and Robert Lee of the College of Pharmacy. Rachel Putman of Brigham and Women’s Hospital in Boston also worked on the study.

The research was supported by grants from the National Institutes of Health and the Department of Defense, and an Ohio State Presidential Fellowship.

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